The Wnt/β-catenin signaling pathway is concerned within the production of extracellular matrix (ECM) by mesangial cells (MCs). Recent research by us and others demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RAs) have protecting results in opposition to diabetic nephropathy. The function of this examine was to analyze whether or not the Wnt/β-catenin signaling in MCs contributed to GLP-1RA-induced inhibition of ECM accumulation and mitigation of glomerular injury in diabetic nephropathy. In cultured human mesangial cells (HMCs), liraglutide (a GLP-1RA) therapy considerably diminished excessive glucose (HG)-stimulated production of fibronectin (FN), collagen IV (Col IV) and α-smooth muscle actin (α-SMA) and the liraglutide results had been considerably attenuated by XAV-939, a selective inhibitor of the Wnt/β-catenin signaling.
Furthermore, HG therapy considerably decreased the protein abundance of Wnt4, Wnt5a, phospho-glycogen synthase kinase-3β and β-catenin. These HG results on the Wnt/β-catenin signaling proteins had been considerably blunted by liraglutide therapy. For in vivo research, we administered liraglutide (200μg/kg/12h) by subcutaneous injection to streptozocin-induced sort 1 diabetic rats for eight weeks. Administration of liraglutide considerably improved elevated blood urine nitrogen, serum creatinine, and urinary albumin excretion charge, and alleviated renal hypertrophy, mesangial growth, and glomerular fibrosis in sort 1 diabetic rats whereas blood glucose stage and physique weight didn’t have vital adjustments.
Consistent with the in vitro research, liraglutide therapy considerably diminished the diabetes-induced will increase in glomerular FN, Col IV and α-SMA, and decreases in glomerular Wnt/β-catenin signaling proteins. These outcomes recommend that liraglutide alleviated glomerular ECM accumulation and renal injury in diabetic nephropathy by enhancing the Wnt/β-catenin signaling.
Transmembrane protein 88 exerts a tumor-inhibitory position in thyroid most cancers via restriction of Wnt/β-catenin signaling
Transmembrane protein 88 (TMEM88) has emerged as a newly found cancer-related protein that acts as a cancer-promoting or cancer-inhibiting regulator in a number of tumor varieties. However, the precise position of TMEM88 in thyroid most cancers is undetermined. The present examine was designed to find out the expression, operate, and potential underlying mechanism of TMEM88 in thyroid most cancers. Our knowledge demonstrated low TMEM88 expression in thyroid most cancers tissues. Decreased TMEM88 expression was additionally present in a number of thyroid most cancers cell traces, and restoration of TMEM88 markedly suppressed the proliferation, colony formation, and invasive potential of thyroid most cancers cells.
On the opposite, TMEM88 depletion considerably accelerated the proliferation, colony formation, and invasion of thyroid most cancers cells. Further experiments documented that TMEM88 overexpression markedly decreased the expression of the energetic type of β-catenin and inhibited the expression of Wnt/β-catenin signaling targets genes, equivalent to c-myc and cyclin D1. Notably, reactivation of Wnt/β-catenin signaling by transfecting a vector that expressed constitutively energetic β-catenin partially reversed the TMEM88-mediated suppressive impact on thyroid most cancers cell proliferation and invasion. In addition, TMEM88 upregulation markedly retarded the tumor development of thyroid most cancers cells in vivo utilizing xenograft fashions related to downregulation of energetic β-catenin expression.
Taken collectively, our findings demonstrated that TMEM88 overexpression impeded the proliferation and invasion of thyroid most cancers cells via downregulation of Wnt/β-catenin signaling. These knowledge point out a possible tumor-suppressive operate of TMEM88 in thyroid most cancers. Our examine highlights a key position for TMEM88 in regulating Wnt/β-catenin signaling through the development of thyroid most cancers and means that TMEM88 is a lovely anticancer goal for thyroid most cancers.

Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling
Spindle and kinetochore-associated protein 2 facilitates the proliferation and invasion of hepatocellular carcinoma through the regulation of Wnt/β-catenin signaling
Recent research have proven that spindle and kinetochore-associated protein 2 (SKA2) is dysregulated in a number of tumors and acts as a key regulator of tumor development. However, whether or not SKA2 performs a job in hepatocellular carcinoma (HCC) has not been totally elucidated. The function of this examine was to discover the expression, operate and underlying molecular mechanism of SKA2 in HCC. We discovered that SKA2 was extremely expressed in HCC tissues and cell traces. Knockdown of SKA2 precipitated marked reductions within the proliferative, colony-forming and invasive capacities of HCC cells, whereas SKA2 overexpression had reverse results. Further experiments revealed that overexpression of SKA2 enhanced expression ranges of phosphorylated glycogen synthase kinase-3β (GSK-3β) and energetic β-catenin in HCC cells.
Nuclear pore complex protein Nup153 Antibody (HRP) |
20-abx108567 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Human Nuclear pore complex protein Nup153 (NUP153) |
1-CSB-EP016190HU |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
|
Description: Recombinant Human Nuclear pore complex protein Nup153(NUP153),partial expressed in E.coli |
Nuclear pore complex protein Nup98 (315-360) |
HY-P1730 |
MedChemExpress |
1mg |
EUR 1140 |
Recombinant human Nuclear pore complex protein Nup133 |
P2220 |
FN Test |
100ug |
Ask for price |
|
Description: Recombinant protein for human Nuclear pore complex protein Nup133 |
Nuclear Pore Complex-Interacting Protein-Like 2 (NPIPL2) Antibody |
abx034938-400ul |
Abbexa |
400 ul |
EUR 523 |
|
Nuclear Pore Complex-Interacting Protein-Like 2 (NPIPL2) Antibody |
abx034938-80l |
Abbexa |
80 µl |
EUR 286 |
|
Human Nuclear pore complex protein Nup155, NUP155 ELISA KIT |
ELI-15040h |
Lifescience Market |
96 Tests |
EUR 824 |
Mouse Nuclear pore complex protein Nup50, Nup50 ELISA KIT |
ELI-15055m |
Lifescience Market |
96 Tests |
EUR 865 |
Human Nuclear pore complex- interacting protein, NPIP ELISA KIT |
ELI-16689h |
Lifescience Market |
96 Tests |
EUR 824 |
Mouse Nuclear pore complex protein Nup54, Nup54 ELISA KIT |
ELI-21319m |
Lifescience Market |
96 Tests |
EUR 865 |
Mouse Nuclear pore complex protein Nup160, Nup160 ELISA KIT |
ELI-21357m |
Lifescience Market |
96 Tests |
EUR 865 |
Mouse Nuclear pore complex protein Nup214, Nup214 ELISA KIT |
ELI-21358m |
Lifescience Market |
96 Tests |
EUR 865 |
Human Nuclear pore complex protein Nup50, NUP50 ELISA KIT |
ELI-22432h |
Lifescience Market |
96 Tests |
EUR 824 |
Bovine Nuclear pore complex protein Nup85, NUP85 ELISA KIT |
ELI-23491b |
Lifescience Market |
96 Tests |
EUR 928 |
Mouse Nuclear pore complex protein Nup85, Nup85 ELISA KIT |
ELI-23492m |
Lifescience Market |
96 Tests |
EUR 865 |
Mouse Nuclear pore complex protein Nup155, Nup155 ELISA KIT |
ELI-44221m |
Lifescience Market |
96 Tests |
EUR 865 |
Human Nuclear pore complex protein Nup214, NUP214 ELISA KIT |
ELI-44222h |
Lifescience Market |
96 Tests |
EUR 824 |
Bovine Nuclear pore complex protein Nup93, NUP93 ELISA KIT |
ELI-44229b |
Lifescience Market |
96 Tests |
EUR 928 |
Mouse Nuclear pore complex protein Nup133, Nup133 ELISA KIT |
ELI-44499m |
Lifescience Market |
96 Tests |
EUR 865 |
Mouse Nuclear pore complex protein Nup93, Nup93 ELISA KIT |
ELI-44561m |
Lifescience Market |
96 Tests |
EUR 865 |
Human Nuclear pore complex protein Nup153, NUP153 ELISA KIT |
ELI-44867h |
Lifescience Market |
96 Tests |
EUR 824 |
Human Nuclear pore complex protein Nup133, NUP133 ELISA KIT |
ELI-46087h |
Lifescience Market |
96 Tests |
EUR 824 |
Mouse Nuclear pore complex protein Nup88, Nup88 ELISA KIT |
ELI-35536m |
Lifescience Market |
96 Tests |
EUR 865 |
Mouse Nuclear pore complex protein Nup107, Nup107 ELISA KIT |
ELI-38239m |
Lifescience Market |
96 Tests |
EUR 865 |
Human Nuclear pore complex protein Nup160, NUP160 ELISA KIT |
ELI-38240h |
Lifescience Market |
96 Tests |
EUR 824 |
Human Nuclear pore complex protein Nup205, NUP205 ELISA KIT |
ELI-38242h |
Lifescience Market |
96 Tests |
EUR 824 |
Human Nuclear pore complex protein Nup85, NUP85 ELISA KIT |
ELI-36779h |
Lifescience Market |
96 Tests |
EUR 824 |
Human Nuclear pore complex protein Nup88, NUP88 ELISA KIT |
ELI-36780h |
Lifescience Market |
96 Tests |
EUR 824 |
Human Nuclear pore complex protein Nup93, NUP93 ELISA KIT |
ELI-36781h |
Lifescience Market |
96 Tests |
EUR 824 |
Human Nuclear pore complex protein Nup107, NUP107 ELISA KIT |
ELI-36840h |
Lifescience Market |
96 Tests |
EUR 824 |
SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody |
20-abx126518 |
Abbexa |
-
EUR 411.00
-
EUR 592.00
-
EUR 182.00
-
EUR 314.00
|
-
100 ul
-
200 ul
-
20 ul
-
50 ul
|
|
SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody |
20-abx123660 |
Abbexa |
|
|
|
SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody |
abx237677-100ug |
Abbexa |
100 ug |
EUR 509 |
|
SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody |
abx025879-400ul |
Abbexa |
400 ul |
EUR 523 |
|
SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody |
abx025879-80l |
Abbexa |
80 µl |
EUR 286 |
|
Human Nuclear pore complex protein Nup98- Nup96, NUP98 ELISA KIT |
ELI-13775h |
Lifescience Market |
96 Tests |
EUR 824 |
ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153) |
KTE100879-48T |
Abbkine |
48T |
EUR 332 |
|
Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153) |
KTE100879-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
|
Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153) |
KTE100879-96T |
Abbkine |
96T |
EUR 539 |
|
Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Nuclear pore membrane glycoprotein 210 Antibody |
20-abx110055 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-100ug |
QP6439-ec-100ug |
EnQuireBio |
100ug |
EUR 408 |
Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-10ug |
QP6439-ec-10ug |
EnQuireBio |
10ug |
EUR 200 |
Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-1mg |
QP6439-ec-1mg |
EnQuireBio |
1mg |
EUR 1632 |
Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-200ug |
QP6439-ec-200ug |
EnQuireBio |
200ug |
EUR 634 |
Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-500ug |
QP6439-ec-500ug |
EnQuireBio |
500ug |
EUR 1060 |
Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-50ug |
QP6439-ec-50ug |
EnQuireBio |
50ug |
EUR 263 |
Nuclear pore membrane glycoprotein 210 Antibody (Biotin) |
20-abx105729 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Nuclear pore membrane glycoprotein 210 Antibody (FITC) |
20-abx107147 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Nuclear pore membrane glycoprotein 210 Antibody (HRP) |
20-abx108568 |
Abbexa |
-
EUR 411.00
-
EUR 1845.00
-
EUR 599.00
-
EUR 182.00
-
EUR 300.00
|
-
100 ug
-
1 mg
-
200 ug
-
20 ug
-
50 ug
|
|
Nuclear Pore Associated Protein 1 (NPAP1) Antibody |
20-abx339916 |
Abbexa |
|
|
|
Nuclear Pore Associated Protein 1 (NPAP1) Antibody |
20-abx339917 |
Abbexa |
|
|
|
Nuclear pore membrane glycoprotein 210 Polyclonal Antibody |
42276-100ul |
SAB |
100ul |
EUR 333 |
Recombinant rat Nuclear pore glycoprotein p62 |
P1858 |
FN Test |
100ug |
Ask for price |
|
Description: Recombinant protein for rat Nuclear pore glycoprotein p62 |
Human SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) ELISA Kit |
abx383083-96tests |
Abbexa |
96 tests |
EUR 911 |
|
Nuclear Pore Membrane Glycoprotein 210-Like (NUP210L) Antibody |
20-abx121185 |
Abbexa |
-
EUR 300.00
-
EUR 439.00
-
EUR 189.00
|
|
|
Nuclear Pore Membrane Glycoprotein 210-Like (NUP210L) Antibody |
20-abx217285 |
Abbexa |
|
|
|
Nuclear pore membrane glycoprotein 210 Polyclonal Conjugated Antibody |
C42276 |
SAB |
100ul |
EUR 397 |
Human Nuclear pore membrane glycoprotein 210 (NUP210) |
1-CSB-EP016195HU(C) |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
|
Description: Recombinant Human Nuclear pore membrane glycoprotein 210(NUP210),partial expressed in E.coli |
Human Nuclear pore membrane glycoprotein 210 (NUP210) |
1-CSB-EP016195HU(N) |
Cusabio |
-
EUR 380.00
-
EUR 214.00
-
EUR 1309.00
-
EUR 560.00
-
EUR 873.00
-
EUR 262.00
|
-
100ug
-
10ug
-
1MG
-
200ug
-
500ug
-
50ug
|
|
Description: Recombinant Human Nuclear pore membrane glycoprotein 210(NUP210),partial expressed in E.coli |
Rabbit anti-Nuclear pore glycoprotein p62 antiserum |
NUP6211-S |
Alpha Diagnostics |
100 ul |
EUR 457 |
Nuclear Pore-Associated Protein 60 kDa-Like (Npap60) Antibody |
abx430652-200ul |
Abbexa |
200 ul |
EUR 384 |
|
Human Nuclear pore glycoprotein p62, NUP62 ELISA KIT |
ELI-22574h |
Lifescience Market |
96 Tests |
EUR 824 |
Mouse Nuclear pore glycoprotein p62, Nup62 ELISA KIT |
ELI-38235m |
Lifescience Market |
96 Tests |
EUR 865 |
Human Nuclear pore membrane glycoprotein 210, NUP210 ELISA KIT |
ELI-19703h |
Lifescience Market |
96 Tests |
EUR 824 |
Mouse Nuclear pore membrane glycoprotein 210, Nup210 ELISA KIT |
ELI-45547m |
Lifescience Market |
96 Tests |
EUR 865 |
Control/Blocking Peptide Nuclear pore membrane glycoprotein Nup210 (GP210) |
GP210-11C |
Alpha Diagnostics |
100 ug |
EUR 225 |
Rabbit anti-Nuclear pore membrane glycoprotein Nup210 (GP210) antiserum |
GP210-11S |
Alpha Diagnostics |
100 ul |
EUR 457 |
Lys proteins Antibody |
DF2705 |
Affbiotech |
200ul |
EUR 304 |
Description: Lys proteins antibody detects endogenous levels of total Lys proteins. |
Lys proteins Antibody |
abx219526-100ug |
Abbexa |
100 ug |
EUR 439 |
|
Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody |
abx238059-100ug |
Abbexa |
100 ug |
EUR 551 |
|
Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody |
20-abx218687 |
Abbexa |
|
|
|
Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody |
20-abx325174 |
Abbexa |
|
|
|
Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-100ug |
QP6440-ec-100ug |
EnQuireBio |
100ug |
EUR 408 |
Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-10ug |
QP6440-ec-10ug |
EnQuireBio |
10ug |
EUR 200 |
Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-1mg |
QP6440-ec-1mg |
EnQuireBio |
1mg |
EUR 1632 |
Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-200ug |
QP6440-ec-200ug |
EnQuireBio |
200ug |
EUR 634 |
Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-500ug |
QP6440-ec-500ug |
EnQuireBio |
500ug |
EUR 1060 |
Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-50ug |
QP6440-ec-50ug |
EnQuireBio |
50ug |
EUR 263 |
ELISA kit for Rat Nuclear envelope pore membrane protein POM 121 (POM121) |
KTE100870-48T |
Abbkine |
48T |
EUR 332 |
|
Description: Quantitative sandwich ELISA for measuring Rat Nuclear envelope pore membrane protein POM 121 (POM121) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Nuclear envelope pore membrane protein POM 121 (POM121) |
KTE100870-5platesof96wells |
Abbkine |
5 plates of 96 wells |
EUR 2115 |
|
Description: Quantitative sandwich ELISA for measuring Rat Nuclear envelope pore membrane protein POM 121 (POM121) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
ELISA kit for Rat Nuclear envelope pore membrane protein POM 121 (POM121) |
KTE100870-96T |
Abbkine |
96T |
EUR 539 |
|
Description: Quantitative sandwich ELISA for measuring Rat Nuclear envelope pore membrane protein POM 121 (POM121) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids. |
Human anti-Nuclear pore glycoprotein p62 IgG ELISA Kit, 96 tests, Quantitative |
NUP62-100 |
Alpha Diagnostics |
1 Kit |
EUR 712 |
Human anti-Nuclear pore glycoprotein p62 IgM ELISA Kit, 96 tests, Quantitative |
NUP62-105 |
Alpha Diagnostics |
1 Kit |
EUR 712 |
Mouse anti-Nuclear pore glycoprotein p62 IgG ELISA Kit, 96 tests, Quantitative |
NUP62-110 |
Alpha Diagnostics |
1 Kit |
EUR 712 |
Rat anti-Nuclear pore glycoprotein p62 IgG ELISA Kit, 96 tests, Quantitative |
NUP62-120 |
Alpha Diagnostics |
1 Kit |
EUR 712 |
Monkey anti-Nuclear pore glycoprotein p62 IgG ELISA Kit, 96 tests, Quantitative |
NUP62-130 |
Alpha Diagnostics |
1 Kit |
EUR 712 |
Recombinant (E.coli) Nuclear pore glycoprotein p62 (Human, 338-522 aa, His-tag) |
NUP62-N-100 |
Alpha Diagnostics |
100 ug |
EUR 286 |
Bone Matrix Proteins |
20-abx265965 |
Abbexa |
-
EUR 384.00
-
EUR 592.00
-
EUR 300.00
|
|
|
Acetyl Lys proteins Polyclonal Antibody |
ABP53385-003ml |
Abbkine |
0.03ml |
EUR 158 |
|
Description: A polyclonal antibody for detection of Acetyl Lys proteins from Human, Mouse, Rat, Monkey. This Acetyl Lys proteins antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human acetylation Lys proteins |
Acetyl Lys proteins Polyclonal Antibody |
ABP53385-01ml |
Abbkine |
0.1ml |
EUR 289 |
|
Description: A polyclonal antibody for detection of Acetyl Lys proteins from Human, Mouse, Rat, Monkey. This Acetyl Lys proteins antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human acetylation Lys proteins |
Acetyl Lys proteins Polyclonal Antibody |
ABP53385-02ml |
Abbkine |
0.2ml |
EUR 414 |
|
Description: A polyclonal antibody for detection of Acetyl Lys proteins from Human, Mouse, Rat, Monkey. This Acetyl Lys proteins antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human acetylation Lys proteins |
Acetyl Lys proteins Polyclonal Antibody |
ES4384-100ul |
ELK Biotech |
100ul |
EUR 279 |
Description: A Rabbit Polyclonal antibody against Acetyl Lys proteins from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
Acetyl Lys proteins Polyclonal Antibody |
ES4384-50ul |
ELK Biotech |
50ul |
EUR 207 |
Description: A Rabbit Polyclonal antibody against Acetyl Lys proteins from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA |
Lys proteins Blocking Peptide |
DF2705-BP |
Affbiotech |
1mg |
EUR 195 |
Anti-Bovine Plasma Proteins |
BPP04 |
Cygnus Technologies |
1 ml |
EUR 334 |
|
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur. |
Anti-Bovine Plasma Proteins |
BPP04-AF |
Cygnus Technologies |
1 mg |
EUR 1913 |
|
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur. |
Anti-Bovine Plasma Proteins |
BPP04-PA |
Cygnus Technologies |
1 ml |
EUR 488 |
|
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur. |
Anti-Bovine Plasma Proteins |
BPP04AF-HRP |
Cygnus Technologies |
100 ul |
EUR 989 |
|
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur. |
serum proteins kit dysproteinaemia |
EHCA1200-KC30-R |
Consort |
ea |
EUR 114 |
Pyruvate Dehydrogenase Complex (PDH Complex) Antibody |
30022-05111 |
AssayPro |
150 ug |
EUR 261 |
Two Pore Segment Channel 1 (TPCN1) Antibody |
abx238882-100ug |
Abbexa |
100 ug |
EUR 551 |
|
botB Complex Antibody |
abx120030-1mg |
Abbexa |
1 mg |
EUR 1567 |
|
HSP90 complex Antibody |
abx440006-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx440287-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx440568-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx440849-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx441130-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx441411-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx441692-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx441973-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx442254-200ug |
Abbexa |
200 ug |
EUR 746 |
|
HSP90 complex Antibody |
abx442535-200ug |
Abbexa |
200 ug |
EUR 746 |
|
HSP90 complex Antibody |
abx442816-200ug |
Abbexa |
200 ug |
EUR 746 |
|
HSP90 complex Antibody |
abx443096-200ug |
Abbexa |
200 ug |
EUR 732 |
|
HSP90 complex Antibody |
abx443376-200ug |
Abbexa |
200 ug |
EUR 732 |
|
HSP90 complex Antibody |
abx443657-200ug |
Abbexa |
200 ug |
EUR 759 |
|
HSP90 complex Antibody |
abx443938-200ug |
Abbexa |
200 ug |
EUR 746 |
|
HSP90 complex Antibody |
abx444219-200ug |
Abbexa |
200 ug |
EUR 746 |
|
HSP90 complex Antibody |
abx444500-200ug |
Abbexa |
200 ug |
EUR 746 |
|
HSP90 complex Antibody |
20-abx444850 |
Abbexa |
|
|
|
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC402984-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF640R conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC402984-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF640R conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNCB2984-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), Biotin conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNCB2984-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), Biotin conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC552984-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF555 conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC552984-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF555 conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC702984-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF770 conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC702984-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF770 conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC432984-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF543 conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC432984-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF543 conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC472984-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF647 conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNC472984-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF647 conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNCAP2984-100 |
Biotium |
100uL |
EUR 233 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody |
BNCAP2984-500 |
Biotium |
500uL |
EUR 545 |
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL |
Moreover, SKA3 overexpression enhanced transcriptional exercise mediated by Wnt/β-catenin signaling. Knockdown of SKA3 downregulated the activation of Wnt/β-catenin signaling, and the impact was considerably reversed by the inhibition of GSK-3β. Notably, inhibition of Wnt/β-catenin signaling markedly abrogated SKA2-mediated promotion impact on HCC proliferation and invasion. In addition, knockdown of SKA2 impeded tumor formation and development in HCC cells in a nude mouse in vivo mannequin. Overall, these findings point out that SKA2 accelerates the development of HCC via the upregulation of Wnt/β-catenin signaling. Our examine highlights a possible position of SKA2 in HCC development and suggests it as a attainable goal for HCC therapy.