Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling

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Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling
Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling

Posted By: Judith Reynolds November 29, 2020

The Wnt/β-catenin signaling pathway is concerned within the production of extracellular matrix (ECM) by mesangial cells (MCs). Recent research by us and others demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RAs) have protecting results in opposition to diabetic nephropathy. The function of this examine was to analyze whether or not the Wnt/β-catenin signaling in MCs contributed to GLP-1RA-induced inhibition of ECM accumulation and mitigation of glomerular injury in diabetic nephropathy. In cultured human mesangial cells (HMCs), liraglutide (a GLP-1RA) therapy considerably diminished excessive glucose (HG)-stimulated production of fibronectin (FN), collagen IV (Col IV) and α-smooth muscle actin (α-SMA) and the liraglutide results had been considerably attenuated by XAV-939, a selective inhibitor of the Wnt/β-catenin signaling.

Furthermore, HG therapy considerably decreased the protein abundance of Wnt4, Wnt5a, phospho-glycogen synthase kinase-3β and β-catenin. These HG results on the Wnt/β-catenin signaling proteins had been considerably blunted by liraglutide therapy. For in vivo research, we administered liraglutide (200μg/kg/12h) by subcutaneous injection to streptozocin-induced sort 1 diabetic rats for eight weeks. Administration of liraglutide considerably improved elevated blood urine nitrogen, serum creatinine, and urinary albumin excretion charge, and alleviated renal hypertrophy, mesangial growth, and glomerular fibrosis in sort 1 diabetic rats whereas blood glucose stage and physique weight didn’t have vital adjustments.

Consistent with the in vitro research, liraglutide therapy considerably diminished the diabetes-induced will increase in glomerular FN, Col IV and α-SMA, and decreases in glomerular Wnt/β-catenin signaling proteins. These outcomes recommend that liraglutide alleviated glomerular ECM accumulation and renal injury in diabetic nephropathy by enhancing the Wnt/β-catenin signaling.

 

Transmembrane protein 88 exerts a tumor-inhibitory position in thyroid most cancers via restriction of Wnt/β-catenin signaling

Transmembrane protein 88 (TMEM88) has emerged as a newly found cancer-related protein that acts as a cancer-promoting or cancer-inhibiting regulator in a number of tumor varieties. However, the precise position of TMEM88 in thyroid most cancers is undetermined. The present examine was designed to find out the expression, operate, and potential underlying mechanism of TMEM88 in thyroid most cancers. Our knowledge demonstrated low TMEM88 expression in thyroid most cancers tissues. Decreased TMEM88 expression was additionally present in a number of thyroid most cancers cell traces, and restoration of TMEM88 markedly suppressed the proliferation, colony formation, and invasive potential of thyroid most cancers cells.
On the opposite, TMEM88 depletion considerably accelerated the proliferation, colony formation, and invasion of thyroid most cancers cells. Further experiments documented that TMEM88 overexpression markedly decreased the expression of the energetic type of β-catenin and inhibited the expression of Wnt/β-catenin signaling targets genes, equivalent to c-myc and cyclin D1. Notably, reactivation of Wnt/β-catenin signaling by transfecting a vector that expressed constitutively energetic β-catenin partially reversed the TMEM88-mediated suppressive impact on thyroid most cancers cell proliferation and invasion. In addition, TMEM88 upregulation markedly retarded the tumor development of thyroid most cancers cells in vivo utilizing xenograft fashions related to downregulation of energetic β-catenin expression.

Taken collectively, our findings demonstrated that TMEM88 overexpression impeded the proliferation and invasion of thyroid most cancers cells via downregulation of Wnt/β-catenin signaling. These knowledge point out a possible tumor-suppressive operate of TMEM88 in thyroid most cancers. Our examine highlights a key position for TMEM88 in regulating Wnt/β-catenin signaling through the development of thyroid most cancers and means that TMEM88 is a lovely anticancer goal for thyroid most cancers.

Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling

Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling

Spindle and kinetochore-associated protein 2 facilitates the proliferation and invasion of hepatocellular carcinoma through the regulation of Wnt/β-catenin signaling

Recent research have proven that spindle and kinetochore-associated protein 2 (SKA2) is dysregulated in a number of tumors and acts as a key regulator of tumor development. However, whether or not SKA2 performs a job in hepatocellular carcinoma (HCC) has not been totally elucidated. The function of this examine was to discover the expression, operate and underlying molecular mechanism of SKA2 in HCC. We discovered that SKA2 was extremely expressed in HCC tissues and cell traces. Knockdown of SKA2 precipitated marked reductions within the proliferative, colony-forming and invasive capacities of HCC cells, whereas SKA2 overexpression had reverse results. Further experiments revealed that overexpression of SKA2 enhanced expression ranges of phosphorylated glycogen synthase kinase-3β (GSK-3β) and energetic β-catenin in HCC cells.

Nuclear pore complex protein Nup153 Antibody (HRP)
20-abx108567
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Human Nuclear pore complex protein Nup153 (NUP153)
1-CSB-EP016190HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Nuclear pore complex protein Nup153(NUP153),partial expressed in E.coli

Nuclear pore complex protein Nup98 (315-360)
HY-P1730 1mg
EUR 1140

Recombinant human Nuclear pore complex protein Nup133
P2220 100ug Ask for price
Description: Recombinant protein for human Nuclear pore complex protein Nup133

Nuclear Pore Complex-Interacting Protein-Like 2 (NPIPL2) Antibody
abx034938-400ul 400 ul
EUR 523

Nuclear Pore Complex-Interacting Protein-Like 2 (NPIPL2) Antibody
abx034938-80l 80 µl
EUR 286

Human Nuclear pore complex protein Nup155, NUP155 ELISA KIT
ELI-15040h 96 Tests
EUR 824

Mouse Nuclear pore complex protein Nup50, Nup50 ELISA KIT
ELI-15055m 96 Tests
EUR 865

Human Nuclear pore complex- interacting protein, NPIP ELISA KIT
ELI-16689h 96 Tests
EUR 824

Mouse Nuclear pore complex protein Nup54, Nup54 ELISA KIT
ELI-21319m 96 Tests
EUR 865

Mouse Nuclear pore complex protein Nup160, Nup160 ELISA KIT
ELI-21357m 96 Tests
EUR 865

Mouse Nuclear pore complex protein Nup214, Nup214 ELISA KIT
ELI-21358m 96 Tests
EUR 865

Human Nuclear pore complex protein Nup50, NUP50 ELISA KIT
ELI-22432h 96 Tests
EUR 824

Bovine Nuclear pore complex protein Nup85, NUP85 ELISA KIT
ELI-23491b 96 Tests
EUR 928

Mouse Nuclear pore complex protein Nup85, Nup85 ELISA KIT
ELI-23492m 96 Tests
EUR 865

Mouse Nuclear pore complex protein Nup155, Nup155 ELISA KIT
ELI-44221m 96 Tests
EUR 865

Human Nuclear pore complex protein Nup214, NUP214 ELISA KIT
ELI-44222h 96 Tests
EUR 824

Bovine Nuclear pore complex protein Nup93, NUP93 ELISA KIT
ELI-44229b 96 Tests
EUR 928

Mouse Nuclear pore complex protein Nup133, Nup133 ELISA KIT
ELI-44499m 96 Tests
EUR 865

Mouse Nuclear pore complex protein Nup93, Nup93 ELISA KIT
ELI-44561m 96 Tests
EUR 865

Human Nuclear pore complex protein Nup153, NUP153 ELISA KIT
ELI-44867h 96 Tests
EUR 824

Human Nuclear pore complex protein Nup133, NUP133 ELISA KIT
ELI-46087h 96 Tests
EUR 824

Mouse Nuclear pore complex protein Nup88, Nup88 ELISA KIT
ELI-35536m 96 Tests
EUR 865

Mouse Nuclear pore complex protein Nup107, Nup107 ELISA KIT
ELI-38239m 96 Tests
EUR 865

Human Nuclear pore complex protein Nup160, NUP160 ELISA KIT
ELI-38240h 96 Tests
EUR 824

Human Nuclear pore complex protein Nup205, NUP205 ELISA KIT
ELI-38242h 96 Tests
EUR 824

Human Nuclear pore complex protein Nup85, NUP85 ELISA KIT
ELI-36779h 96 Tests
EUR 824

Human Nuclear pore complex protein Nup88, NUP88 ELISA KIT
ELI-36780h 96 Tests
EUR 824

Human Nuclear pore complex protein Nup93, NUP93 ELISA KIT
ELI-36781h 96 Tests
EUR 824

Human Nuclear pore complex protein Nup107, NUP107 ELISA KIT
ELI-36840h 96 Tests
EUR 824

SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
20-abx126518
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
20-abx123660
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul

SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
abx237677-100ug 100 ug
EUR 509

SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
abx025879-400ul 400 ul
EUR 523

SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) Antibody
abx025879-80l 80 µl
EUR 286

Human Nuclear pore complex protein Nup98- Nup96, NUP98 ELISA KIT
ELI-13775h 96 Tests
EUR 824

ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153)
KTE100879-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153)
KTE100879-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Nuclear pore complex protein Nup153 (NUP153)
KTE100879-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Rat Nuclear pore complex protein Nup153 (NUP153) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Nuclear pore membrane glycoprotein 210 Antibody
20-abx110055
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-100ug
QP6439-ec-100ug 100ug
EUR 408

Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-10ug
QP6439-ec-10ug 10ug
EUR 200

Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-1mg
QP6439-ec-1mg 1mg
EUR 1632

Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-200ug
QP6439-ec-200ug 200ug
EUR 634

Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-500ug
QP6439-ec-500ug 500ug
EUR 1060

Recombinant Human Nuclear pore complex protein Nup153 Protein, His, E.coli-50ug
QP6439-ec-50ug 50ug
EUR 263

Nuclear pore membrane glycoprotein 210 Antibody (Biotin)
20-abx105729
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nuclear pore membrane glycoprotein 210 Antibody (FITC)
20-abx107147
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nuclear pore membrane glycoprotein 210 Antibody (HRP)
20-abx108568
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Nuclear Pore Associated Protein 1 (NPAP1) Antibody
20-abx339916
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Nuclear Pore Associated Protein 1 (NPAP1) Antibody
20-abx339917
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul

Nuclear pore membrane glycoprotein 210 Polyclonal Antibody
42276-100ul 100ul
EUR 333

Recombinant rat Nuclear pore glycoprotein p62
P1858 100ug Ask for price
Description: Recombinant protein for rat Nuclear pore glycoprotein p62

Human SEC13 Homolog, Nuclear Pore And COPII Coat Complex Component (SEC13) ELISA Kit
abx383083-96tests 96 tests
EUR 911

Nuclear Pore Membrane Glycoprotein 210-Like (NUP210L) Antibody
20-abx121185
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul

Nuclear Pore Membrane Glycoprotein 210-Like (NUP210L) Antibody
20-abx217285
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

Nuclear pore membrane glycoprotein 210 Polyclonal Conjugated Antibody
C42276 100ul
EUR 397

Human Nuclear pore membrane glycoprotein 210 (NUP210)
1-CSB-EP016195HU(C)
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Nuclear pore membrane glycoprotein 210(NUP210),partial expressed in E.coli

Human Nuclear pore membrane glycoprotein 210 (NUP210)
1-CSB-EP016195HU(N)
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
Description: Recombinant Human Nuclear pore membrane glycoprotein 210(NUP210),partial expressed in E.coli

Rabbit anti-Nuclear pore glycoprotein p62 antiserum
NUP6211-S 100 ul
EUR 457

Nuclear Pore-Associated Protein 60 kDa-Like (Npap60) Antibody
abx430652-200ul 200 ul
EUR 384

Human Nuclear pore glycoprotein p62, NUP62 ELISA KIT
ELI-22574h 96 Tests
EUR 824

Mouse Nuclear pore glycoprotein p62, Nup62 ELISA KIT
ELI-38235m 96 Tests
EUR 865

Human Nuclear pore membrane glycoprotein 210, NUP210 ELISA KIT
ELI-19703h 96 Tests
EUR 824

Mouse Nuclear pore membrane glycoprotein 210, Nup210 ELISA KIT
ELI-45547m 96 Tests
EUR 865

Control/Blocking Peptide Nuclear pore membrane glycoprotein Nup210 (GP210)
GP210-11C 100 ug
EUR 225

Rabbit anti-Nuclear pore membrane glycoprotein Nup210 (GP210) antiserum
GP210-11S 100 ul
EUR 457

Lys proteins Antibody
ABD2705 100 ug
EUR 438

Lys proteins Antibody
DF2705 200ul
EUR 304
Description: Lys proteins antibody detects endogenous levels of total Lys proteins.

Lys proteins Antibody
abx219526-100ug 100 ug
EUR 439

Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody
abx238059-100ug 100 ug
EUR 551

Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody
20-abx218687
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug

Small Nuclear RNA Activating Complex Polypeptide 5 (SNAPC5) Antibody
20-abx325174
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug

Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-100ug
QP6440-ec-100ug 100ug
EUR 408

Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-10ug
QP6440-ec-10ug 10ug
EUR 200

Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-1mg
QP6440-ec-1mg 1mg
EUR 1632

Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-200ug
QP6440-ec-200ug 200ug
EUR 634

Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-500ug
QP6440-ec-500ug 500ug
EUR 1060

Recombinant Human Nuclear pore membrane glycoprotein 210 Protein, His, E.coli-50ug
QP6440-ec-50ug 50ug
EUR 263

ELISA kit for Rat Nuclear envelope pore membrane protein POM 121 (POM121)
KTE100870-48T 48T
EUR 332
Description: Quantitative sandwich ELISA for measuring Rat Nuclear envelope pore membrane protein POM 121 (POM121) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Nuclear envelope pore membrane protein POM 121 (POM121)
KTE100870-5platesof96wells 5 plates of 96 wells
EUR 2115
Description: Quantitative sandwich ELISA for measuring Rat Nuclear envelope pore membrane protein POM 121 (POM121) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Rat Nuclear envelope pore membrane protein POM 121 (POM121)
KTE100870-96T 96T
EUR 539
Description: Quantitative sandwich ELISA for measuring Rat Nuclear envelope pore membrane protein POM 121 (POM121) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Human anti-Nuclear pore glycoprotein p62 IgG ELISA Kit, 96 tests, Quantitative
NUP62-100 1 Kit
EUR 712

Human anti-Nuclear pore glycoprotein p62 IgM ELISA Kit, 96 tests, Quantitative
NUP62-105 1 Kit
EUR 712

Mouse anti-Nuclear pore glycoprotein p62 IgG ELISA Kit, 96 tests, Quantitative
NUP62-110 1 Kit
EUR 712

Rat anti-Nuclear pore glycoprotein p62 IgG ELISA Kit, 96 tests, Quantitative
NUP62-120 1 Kit
EUR 712

Monkey anti-Nuclear pore glycoprotein p62 IgG ELISA Kit, 96 tests, Quantitative
NUP62-130 1 Kit
EUR 712

Recombinant (E.coli) Nuclear pore glycoprotein p62 (Human, 338-522 aa, His-tag)
NUP62-N-100 100 ug
EUR 286

Bone Matrix Proteins
5-00844 4 x 5mg Ask for price

Bone Matrix Proteins
20-abx265965
  • EUR 384.00
  • EUR 592.00
  • EUR 300.00
  • 10 mg
  • 25 mg
  • 5 mg

Acetyl Lys proteins Polyclonal Antibody
ABP53385-003ml 0.03ml
EUR 158
Description: A polyclonal antibody for detection of Acetyl Lys proteins from Human, Mouse, Rat, Monkey. This Acetyl Lys proteins antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human acetylation Lys proteins

Acetyl Lys proteins Polyclonal Antibody
ABP53385-01ml 0.1ml
EUR 289
Description: A polyclonal antibody for detection of Acetyl Lys proteins from Human, Mouse, Rat, Monkey. This Acetyl Lys proteins antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human acetylation Lys proteins

Acetyl Lys proteins Polyclonal Antibody
ABP53385-02ml 0.2ml
EUR 414
Description: A polyclonal antibody for detection of Acetyl Lys proteins from Human, Mouse, Rat, Monkey. This Acetyl Lys proteins antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human acetylation Lys proteins

Acetyl Lys proteins Polyclonal Antibody
ES4384-100ul 100ul
EUR 279
Description: A Rabbit Polyclonal antibody against Acetyl Lys proteins from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Acetyl Lys proteins Polyclonal Antibody
ES4384-50ul 50ul
EUR 207
Description: A Rabbit Polyclonal antibody against Acetyl Lys proteins from Human/Mouse/Rat/Monkey. This antibody is tested and validated for WB, ELISA, IHC, IF, WB, ELISA

Lys proteins Blocking Peptide
DF2705-BP 1mg
EUR 195

Anti-Bovine Plasma Proteins
BPP04 1 ml
EUR 334
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins
BPP04-AF 1 mg
EUR 1913
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins
BPP04-PA 1 ml
EUR 488
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins
BPP04AF-HRP 100 ul
EUR 989
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

serum proteins kit dysproteinaemia
EHCA1200-KC30-R ea
EUR 114

Pyruvate Dehydrogenase Complex (PDH Complex) Antibody
30022-05111 150 ug
EUR 261

Two Pore Segment Channel 1 (TPCN1) Antibody
abx238882-100ug 100 ug
EUR 551

botB Complex Antibody
abx120030-1mg 1 mg
EUR 1567

HSP90 complex Antibody
abx440006-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx440287-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx440568-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx440849-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx441130-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx441411-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx441692-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx441973-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx442254-200ug 200 ug
EUR 746

HSP90 complex Antibody
abx442535-200ug 200 ug
EUR 746

HSP90 complex Antibody
abx442816-200ug 200 ug
EUR 746

HSP90 complex Antibody
abx443096-200ug 200 ug
EUR 732

HSP90 complex Antibody
abx443376-200ug 200 ug
EUR 732

HSP90 complex Antibody
abx443657-200ug 200 ug
EUR 759

HSP90 complex Antibody
abx443938-200ug 200 ug
EUR 746

HSP90 complex Antibody
abx444219-200ug 200 ug
EUR 746

HSP90 complex Antibody
abx444500-200ug 200 ug
EUR 746

HSP90 complex Antibody
20-abx444850
  • EUR 648.00
  • EUR 384.00
  • 200 ug
  • 50 ug

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC402984-100 100uL
EUR 233
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF640R conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC402984-500 500uL
EUR 545
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF640R conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNCB2984-100 100uL
EUR 233
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), Biotin conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNCB2984-500 500uL
EUR 545
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), Biotin conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC552984-100 100uL
EUR 233
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF555 conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC552984-500 500uL
EUR 545
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF555 conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC702984-100 100uL
EUR 233
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF770 conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC702984-500 500uL
EUR 545
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF770 conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC432984-100 100uL
EUR 233
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF543 conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC432984-500 500uL
EUR 545
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF543 conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC472984-100 100uL
EUR 233
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF647 conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNC472984-500 500uL
EUR 545
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), CF647 conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNCAP2984-100 100uL
EUR 233
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

Nuclear Antigen (Pan-Nuclear Marker) (NM2984R) Antibody
BNCAP2984-500 500uL
EUR 545
Description: Primary antibody against Nuclear Antigen (Pan-Nuclear Marker) (NM2984R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
Moreover, SKA3 overexpression enhanced transcriptional exercise mediated by Wnt/β-catenin signaling. Knockdown of SKA3 downregulated the activation of Wnt/β-catenin signaling, and the impact was considerably reversed by the inhibition of GSK-3β. Notably, inhibition of Wnt/β-catenin signaling markedly abrogated SKA2-mediated promotion impact on HCC proliferation and invasion. In addition, knockdown of SKA2 impeded tumor formation and development in HCC cells in a nude mouse in vivo mannequin. Overall, these findings point out that SKA2 accelerates the development of HCC via the upregulation of Wnt/β-catenin signaling. Our examine highlights a possible position of SKA2 in HCC development and suggests it as a attainable goal for HCC therapy.