Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.
Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Ischemic retinopathies are characterised by a progressive microvascular degeneration adopted by a postischemic aberrant neovascularization. To reinstate vascular provide and metabolic equilibrium to the ischemic tissue throughout ischemic retinopathies, a dysregulated manufacturing of progress components and metabolic intermediates happens, selling retinal angiogenesis. Glycolysis-derived lactate, extremely produced throughout ischemic situations, has been related to tumor angiogenesis and wound therapeutic. Lactate exerts its organic results via G-protein-coupled receptor 81 (GPR81) in a number of tissues; nevertheless, its physiological capabilities and mechanisms of motion within the retina stay poorly understood.

Herein, we present that GPR81, localized predominantly in Müller cells, governs deep vascular advanced formation throughout improvement and in ischemic retinopathy. Lactate-stimulated GPR81 Müller cells produce quite a few angiogenic components, together with Wnt ligands and significantly Norrin, which contributes considerably in triggering internal retinal blood vessel formation. Conversely, GPR81-null mice retina reveals decreased internal vascular community formation related to low ranges of Norrin (and Wnt ligands). Lactate accumulation throughout ischemic retinopathy selectively prompts GPR81-extracellular signal-regulated kinase 1\/2-Norrin signaling to speed up internal retinal vascularization in wild-type animals, however not within the retina of GPR81-null mice. Altogether, we reveal that lactate via GPR81-Norrin participates in internal vascular community improvement and in restoration of the vasculature in response to harm. These findings counsel a brand new potential therapeutic goal to alleviate ischemic illnesses.

Wnts and Hedgehogs (Hh) are giant, lipid-modified extracellular morphogens that play key roles in embryonic improvement and stem cell proliferation of Metazoa. Both morphogens sign by way of heptahelical Frizzled-type receptors of the G-Protein Coupled Receptor household and there are a number of different similarities that counsel a typical evolutionary origin of the Hh and Wnt pathways. There is proof that the secreted protein, Wnt inhibitory issue 1 (WIF1) modulates the exercise of each Wnts and Hhs and will thus contribute to the intertwining of those pathways. In this text, we evaluate the construction, evolution, molecular interactions and capabilities of WIF1 with main emphasis on its position in carcinogenesis.

 

Accumulation of Progerin Affects the Symmetry of Cell Division and Is Associated with Impaired Wnt Signaling and the Mislocalization of Nuclear Envelope Proteins.

Hutchinson-Gilford progeria syndrome (HGPS) is the results of a faulty type of the lamin A protein referred to as progerin. While progerin is understood to disrupt the properties of the nuclear lamina, the underlying mechanisms liable for the pathophysiology of HGPS stay much less clear. Previous research in our laboratory have proven that progerin expression in murine epidermal basal cells leads to impaired stratification and halted improvement of the pores and skin. Stratification and differentiation of the dermis is regulated by uneven stem cell division. Here, we present that expression of progerin impairs the flexibility of stem cells to keep up tissue homeostasis on account of altered cell division. Quantification of basal pores and skin cells confirmed a rise in symmetric cell division that correlated with progerin accumulation in HGPS mice. Investigation of the mechanisms underlying this phenomenon revealed a putative position of Wnt/β-catenin signaling. Further evaluation urged an alteration within the nuclear translocation of β-catenin involving the internal and outer nuclear membrane proteins, emerin and nesprin-2.
Taken collectively, our outcomes counsel a direct involvement of progerin within the transmission of Wnt signaling and regular stem cell division. These insights into the molecular mechanisms of progerin might assist develop new remedy methods for HGPS. Wnts are lipid-modified proteins that regulate stem cell signaling via Frizzled receptors on the cell floor. Determination of binding interactions between lipid-modified Wnt proteins and their Frizzled receptors has been difficult because of the lack of availability of facile detection strategies and technical hurdles related to producing the related reagents.

Here we report an enzyme-linked immunosorbent assay to measure the binding of a biotinylated type of lipid-modified Wnt3a to the extracellular cysteine-rich area of Frizzled receptor. The technique described herein is powerful and fast, makes use of minimal volumes of reagents, and may be carried out in a high-throughput format. Because of those attributes, the strategy may discover utility in drug discovery purposes reminiscent of characterizing the impact of pharmacological inhibitors on Wnt signaling with out the necessity for stylish biophysical instrumentation.

 Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

[Expression and significance of dishevelled proteins in the Wnt pathway in childhood acute lymphoblastic leukemia].

To research the importance of dishevelled (DVL) proteins within the Wnt signaling pathway within the pathogenesis and prognosis of childhood acute lymphoblastic leukemia (ALL).At analysis and on day 33 of induction remedy, 2 mL bone marrow samples had been collected from the case and management teams, and qRT-PCR was used to measure the mRNA expression of DVL1, DVL2 and DVL3 in blood cells of bone marrow.The mRNA expression of DVL1, DVL2 and DVL3 within the case group within the incipient stage was considerably larger than that within the remission stage and the management group . Compared with the management group, the case group had a major improve within the mRNA expression of DVL2 within the remission stage.

Human Bone morphogenetic proteins ELISA kit

E01B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Human Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human Bone morphogenetic proteins ELISA kit

E01B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Human Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Bone morphogenetic proteins ELISA kit

E03B0682-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Mouse Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Bone morphogenetic proteins ELISA kit

E03B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Mouse Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Mouse Bone morphogenetic proteins ELISA kit

E03B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Mouse Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Bone morphogenetic proteins ELISA kit

E06B0682-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Goat Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Bone morphogenetic proteins ELISA kit

E06B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Goat Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Goat Bone morphogenetic proteins ELISA kit

E06B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Goat Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Bone morphogenetic proteins ELISA kit

E04B0682-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Rabbit Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Bone morphogenetic proteins ELISA kit

E04B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Rabbit Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rabbit Bone morphogenetic proteins ELISA kit

E04B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Rabbit Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Bone morphogenetic proteins ELISA kit

E02B0682-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Rat Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Bone morphogenetic proteins ELISA kit

E02B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Rat Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat Bone morphogenetic proteins ELISA kit

E02B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Rat Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Bone morphogenetic proteins ELISA kit

E07B0682-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
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Description: A competitive for quantitative measurement of Porcine Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Bone morphogenetic proteins ELISA kit

E07B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Porcine Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig Bone morphogenetic proteins ELISA kit

E07B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Porcine Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Bovine bone morphogenetic proteins ELISA Kit

ELA-E0653b 96 Tests
EUR 928

Human bone morphogenetic proteins ELISA Kit

ELA-E0653h 96 Tests
EUR 824

Rabbit bone morphogenetic proteins ELISA Kit

ELA-E0653Rb 96 Tests
EUR 928

Dog Bone morphogenetic proteins ELISA kit

E08B0682-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Canine Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Bone morphogenetic proteins ELISA kit

E08B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Canine Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Dog Bone morphogenetic proteins ELISA kit

E08B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Canine Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Bone morphogenetic proteins ELISA kit

E09B0682-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Monkey Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Bone morphogenetic proteins ELISA kit

E09B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Monkey Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Monkey Bone morphogenetic proteins ELISA kit

E09B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Monkey Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Human bone morphogenetic proteins,BMPs ELISA Kit

201-12-1469 96 tests
EUR 440
  • This bone morphogenetic proteins ELISA kit is validated to work with samples from whole blood, serum, plasma and cell culture supernatant.
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.

Guinea pig Bone morphogenetic proteins ELISA kit

E05B0682-192T 192 tests
EUR 1270
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Guinea pig Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Bone morphogenetic proteins ELISA kit

E05B0682-48 1 plate of 48 wells
EUR 520
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Guinea pig Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Guinea pig Bone morphogenetic proteins ELISA kit

E05B0682-96 1 plate of 96 wells
EUR 685
  • Kit contents: 1. MICROTITER PLATE * 1 2. ENZYME CONJUGATE*1 vial 3. STANDARD A*1 vial 4. STANDARD B*1 vial 5. STANDARD C*1 vial 6. STANDARD D*1 vial 7. STANDARD E*1 vial 8. STANDARD F*1 vial 9. SUBSTRATE A*1 vial 10. SUBSTRATE B*1 vial 11. STOP SOLUT
  • Show more
Description: A competitive for quantitative measurement of Guinea pig Bone morphogenetic proteins in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat bone morphogenetic proteins,BMPs ELISA Kit

CN-01673R1 96T
EUR 442

Rat bone morphogenetic proteins,BMPs ELISA Kit

CN-01673R2 48T
EUR 293

Mouse bone morphogenetic proteins,BMPs ELISA Kit

CN-02545M1 96T
EUR 451

Mouse bone morphogenetic proteins,BMPs ELISA Kit

CN-02545M2 48T
EUR 300

Human bone morphogenetic proteins,BMPs ELISA Kit

CN-03974H1 96T
EUR 442

Human bone morphogenetic proteins,BMPs ELISA Kit

CN-03974H2 48T
EUR 293

Rabbit bone morphogenetic proteins,BMPs ELISA Kit

GA-E0043RB-48T 48T
EUR 326

Rabbit bone morphogenetic proteins,BMPs ELISA Kit

GA-E0043RB-96T 96T
EUR 524

Human bone morphogenetic proteins(BMPs)ELISA Kit

GA-E1485HM-48T 48T
EUR 289

Human bone morphogenetic proteins(BMPs)ELISA Kit

GA-E1485HM-96T 96T
EUR 466

Mouse bone morphogenetic proteins(BMPs)ELISA Kit  

GA-E0483MS-48T 48T
EUR 336

Mouse bone morphogenetic proteins(BMPs)ELISA Kit  

GA-E0483MS-96T 96T
EUR 534

Rat bone morphogenetic proteins(BMPs)ELISA Kit

GA-E0283RT-48T 48T
EUR 317

Rat bone morphogenetic proteins(BMPs)ELISA Kit

GA-E0283RT-96T 96T
EUR 496

Human bone morphogenetic proteins(BMPs)ELISA Kit

QY-E03295 96T
EUR 361

Rat bone morphogenetic proteins(BMPs)ELISA Kit

QY-E11369 96T
EUR 400

Mouse bone morphogenetic proteins(BMPs)ELISA Kit

QY-E20215 96T
EUR 361

Rabbit bone morphogenetic proteins,BMPs ELISA Kit

QY-E30260 96T
EUR 374

Bone Matrix Proteins

5-00844 4 x 5mg Ask for price

Bone Matrix Proteins

20-abx265965
  • EUR 384.00
  • EUR 592.00
  • EUR 300.00
  • 10 mg
  • 25 mg
  • 5 mg
  • Shipped within 5-10 working days.

Bone Morphogenetic protein-7 Protein

20-abx260413
  • EUR 230.00
  • EUR 2332.00
  • EUR 328.00
  • 10 ug
  • 1 mg
  • 50 ug
  • Shipped within 5-10 working days.

Bone Morphogenetic protein-4 Protein

20-abx261737
  • EUR 328.00
  • EUR 3599.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Bone Morphogenetic protein-5 Protein

20-abx261756
  • EUR 3766.00
  • EUR 328.00
  • EUR 230.00
  • 1 mg
  • 20 ug
  • 5 ug
  • Shipped within 5-10 working days.

Bone Morphogenetic protein-7 Protein

20-abx261876
  • EUR 328.00
  • EUR 4490.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Bone morphogenetic protein 2 (BMP2)

E62K008 20ug
EUR 343

Bone morphogenetic protein 7 (BMP7)

E62K009 20ug
EUR 343

Bone Morphogenetic protein-2 Protein

20-abx262193
  • EUR 328.00
  • EUR 4365.00
  • EUR 230.00
  • 10 ug
  • 1 mg
  • 2 µg
  • Shipped within 5-10 working days.

Recombinant Human Bone Morphogenetic protein-2

7-00169 2µg Ask for price

Recombinant Human Bone Morphogenetic protein-2

7-00170 10µg Ask for price

Recombinant Human Bone Morphogenetic protein-2

7-00171 1mg Ask for price

Recombinant Human Bone Morphogenetic protein-4

7-00178 2µg Ask for price

Recombinant Human Bone Morphogenetic protein-4

7-00179 10µg Ask for price

Recombinant Human Bone Morphogenetic protein-4

7-00180 1mg Ask for price

Recombinant Human Bone Morphogenetic protein-5

7-00181 5µg Ask for price

Recombinant Human Bone Morphogenetic protein-5

7-00182 20µg Ask for price

Recombinant Human Bone Morphogenetic protein-5

7-00183 1mg Ask for price

Recombinant Human Bone Morphogenetic protein-7

7-00184 2µg Ask for price

Recombinant Human Bone Morphogenetic protein-7

7-00185 10µg Ask for price

Recombinant Human Bone Morphogenetic protein-7

7-00186 1mg Ask for price

Bone morphogenetic protein 3 Polyclonal Antibody

42083-100ul 100ul
EUR 333

Bone morphogenetic protein 7 Polyclonal Antibody

42441-100ul 100ul
EUR 333

Bone morphogenetic protein 2 Polyclonal Antibody

42505-100ul 100ul
EUR 333

Bone morphogenetic protein 6 Polyclonal Antibody

42530-100ul 100ul
EUR 333

Human Bone morphogenetic protein 1 (BMP1)

1-CSB-EP002733HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 102 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 1(BMP1) expressed in E.coli

Human Bone morphogenetic protein 2 (BMP2)

1-CSB-EP002736HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 16.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 2(BMP2) expressed in E.coli

Human Bone morphogenetic protein 2 (BMP2)

1-CSB-EP002736HUa2
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 28.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 2(BMP2) expressed in E.coli

Human Bone morphogenetic protein 3 (BMP3)

1-CSB-EP002739HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 16.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 3(BMP3) expressed in E.coli

Human Bone morphogenetic protein 3 (BMP3)

1-CSB-EP002739HUf1
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 13.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 3(BMP3) expressed in E.coli

Mouse Bone morphogenetic protein 3 (Bmp3)

1-CSB-EP002739MO
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 13.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Mouse Bone morphogenetic protein 3(Bmp3) expressed in E.coli

Human Bone morphogenetic protein 4 (BMP4)

1-CSB-EP002740HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 29.1 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 4(BMP4) expressed in E.coli

Human Bone morphogenetic protein 7 (BMP7)

1-CSB-EP002744HU
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 19.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 7(BMP7) expressed in E.coli

Human Bone morphogenetic protein 7 (BMP7)

1-CSB-EP002744HUe0
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 42.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 7(BMP7) expressed in E.coli

Mouse Bone morphogenetic protein 8B (Bmp8b)

1-CSB-EP002746MO
  • EUR 611.00
  • EUR 309.00
  • EUR 1827.00
  • EUR 939.00
  • EUR 1218.00
  • EUR 397.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 28.7 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Mouse Bone morphogenetic protein 8B(Bmp8b) expressed in E.coli

Human Bone morphogenetic protein 6 (BMP6)

1-CSB-RP107094h
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 18.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 6(BMP6),partial expressed in E.coli

Human Bone morphogenetic protein 2 (BMP2)

1-CSB-YP002736HU
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 14.9 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 2(BMP2) expressed in Yeast

Human Bone morphogenetic protein 3 (BMP3)

1-CSB-YP002739HU
  • EUR 504.00
  • EUR 265.00
  • EUR 1832.00
  • EUR 763.00
  • EUR 1216.00
  • EUR 334.00
  • 100ug
  • 10ug
  • 1MG
  • 200ug
  • 500ug
  • 50ug
  • MW: 16.4 kDa
  • Buffer composition: Tris-based buffer with 50% glycerol.
Description: Recombinant Human Bone morphogenetic protein 3(BMP3) expressed in Yeast

Active Bone Morphogenetic Protein 2 (BMP2)

4-APA013Hu02
  • EUR 798.88
  • EUR 317.00
  • EUR 2720.80
  • EUR 973.60
  • EUR 1847.20
  • EUR 598.00
  • EUR 6652.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P12643
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): Inquire
  • Isoelectric Point: 9.2
Description: Recombinant Human Active Bone Morphogenetic Protein 2 (BMP2) expressed in: Available from E.coli, Yeast, Baculovirus and Mammalian cells

Active Bone Morphogenetic Protein 4 (BMP4)

4-APA014Hu02
  • EUR 816.80
  • EUR 322.00
  • EUR 2788.00
  • EUR 996.00
  • EUR 1892.00
  • EUR 610.00
  • EUR 6820.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P12644
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 48.0kDa
  • Isoelectric Point: 9
Description: Recombinant Human Bone Morphogenetic Protein 4 expressed in: E.coli

Active Bone Morphogenetic Protein 7 (BMP7)

4-APA799Mu01
  • EUR 740.64
  • EUR 301.00
  • EUR 2502.40
  • EUR 900.80
  • EUR 1701.60
  • EUR 559.00
  • EUR 6106.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P23359
  • Buffer composition: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 16kDa
  • Isoelectric Point: 8.5
Description: Recombinant Mouse Bone Morphogenetic Protein 7 expressed in: E.coli

Bone Morphogenetic Protein 3 (BMP3) Antibody

20-abx007127
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 15 (BMP15) Antibody

20-abx007171
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 3 (BMP3) Antibody

20-abx007201
  • EUR 411.00
  • EUR 592.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 50 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 8B (BMP8B) Antibody

20-abx007570
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 8A (BMP8A) Antibody

20-abx007910
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 10 (BMP10) Antibody

20-abx008191
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 7 (BMP7) Antibody

20-abx009546
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 5 (BMP5) Antibody

20-abx009547
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 3 (BMP3A) Antibody

20-abx009548
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Bone Morphogenetic Protein 3 (BMP3) Antibody

20-abx009549
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.
The mRNA expression of DVL2 was considerably larger than that of DVL1 and DVL3 in each remission and incipient phases. The high- and intermediate-risk teams had considerably larger mRNA expression of DVL1 and DVL2 than the low-risk group. The mRNA expression of DVL2 was considerably larger than that of DVL1 and DVL3 within the low-, intermediate- and high-risk teams (P<0.05).The change within the expression of DVL, particularly DVL2, within the Wnt sign pathway has sure significance within the pathogenesis and prognosis of childhood ALL.