Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression

Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression
Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression

Today, pancreatic cancer (PC) is a serious well being downside within the United States. It stays a problem to develop efficacious clinically helpful PC therapies. New avenues, primarily based on translational approaches and progressive validated biomarkers might be a preclinical choice to guage PC drug candidates or drug combos earlier than medical trials. Herein, we describe analysis of mixture therapies by incorporating a novel pathway modulator, p53-Activator Wnt Inhibitor-2 (PAWI-2) with different FDA-approved cancer medication which were utilized in PC medical trials. PAWI-2 is a potent inhibitor of drug-resistant PC cells that has been proven to selectively ameliorate human pancreatic cancer stem cells (i.e., hPCSCs, FGβ3 cells).

 

In the current examine, we confirmed PAWI-2 produced therapeutic synergism with sure varieties of anti-cancer medication. These medication themselves oftentimes don’t ameliorate PC cells (particularly PCSCs) resulting from excessive ranges of drug-resistance. PAWI-2 has the power to rescue the efficiency of medication (i.e., erlotinib, trametinib) and inhibit PC cell progress. Key molecular regulators of PAWI-2 might be used to foretell synergistic/antagonistic results between PAWI-2 and different anti-cancer medication. Anti-cancer outcomes confirmed efficiency might be fairly precisely correlated to phosphorylation of optineurin (OPTN) in PC cells. Synergism/antagonism was additionally related to inhibition of PCSC marker SOX2 that was noticed in FGβ3 cells. Synergism broadens the potential use of PAWI-2 as an adjunct chemotherapy in sufferers with PC which have developed resistance to first-line focused therapies or chemotherapies.

 

Bone formation round unstable implants is enhanced by a WNT protein therapeutic in a preclinical in vivo mannequin

Objectives: Our goal was to check the speculation that native supply of a WNT protein therapeutic would help osseointegration of an unstable implant positioned into an outsized osteotomy and subjected to practical loading.
Materials and strategies: Using a split-mouth design in an ovariectomized (OVX) rat mannequin, 50 titanium implants had been positioned in outsized osteotomies. Implants had been subjected to practical loading. One-half of the implants had been handled with a liposomal formulation of WNT3A protein (L-WNT3A); the opposite half acquired an an identical liposomal formulation containing phosphate buffered saline (PBS). Finite ingredient modeling estimated peri-implant strains precipitated by practical loading. Histological, molecular, mobile, and quantitative micro-computed tomographic (µCT) imaging analyses had been carried out on samples from post-implant days (PID) 3, 7, and 14. Lateral implant stability was quantified at PID7 and 14.
Results: Finite ingredient analyses predicted ranges of peri-implant strains incompatible with new bone formation. Micro-CT imaging, histological, and quantitative immunohistochemical (IHC) analyses confirmed that PBS-treated implants underwent fibrous encapsulation. In these instances the place the peri-implant setting was handled with L-WNT3A, µCT imaging, histological, and quantitative IHC analyses demonstrated a big improve in expression of proliferative (PCNA) and osteogenic (Runx2, Osterix) markers. One week after L-WNT3A therapy, new bone formation was evident and two weeks later, L-WNT3A handled gaps had a stiffer interface in comparison with PBS-treated gaps.

Conclusion: In a rat mannequin, unstable implants bear fibrous encapsulation. If the identical unstable implants are handled with L-WNT3A on the time of placement, then it leads to considerably extra peri-implant bone and higher interfacial stiffness.

 Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression

Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression

Ark shell protein-derived bioactive peptides promote osteoblastic differentiation by means of upregulation of the canonical Wnt/β-catenin signaling in human bone marrow-derived mesenchymal stem cells

In this examine, the stimulating impact of ark shell protein-derived peptides AWLNH and PHDL on osteoblast differentiation in human bone marrow-derived mesenchymal stem cells (hBMMSCs) and its molecular mechanism was investigated. The hBMMSCs had been cultured with two peptides and osteogenic markers had been analyzed. Results confirmed that enhanced ALP exercise and calcification had been detected within the presence of AWLNH and PHDL. Based on western blotting, RT-qPCR, and immunostaining evaluation, AWLNH and PHDL are particular for osteoblast differentiation of hBMMSCs by means of activating the canonical Wnt/β-catenin signaling pathway adopted by activating Runx2, osterix, and kind I collagen. Loss-of-function assay with DKK-1, a Wnt antagonist, confirmed that the canonical Wnt/β-catenin signaling was important for AWLNH and PHDL-induced osteogenesis in hBMMSCs.

Anti-Total Goat Milk Proteins

4042-PA 1 ml
EUR 488
  • Product category: Antibodies
Description: Anti-Total Goat Milk Proteins by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A 1000 ml
EUR 565
  • Product category: Buffer solution
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A-100 100 ml
EUR 257
  • Product category: Buffer solution
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A-500 500 ml
EUR 411
  • Product category: Buffer solution
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Antigen Concentrate

F243H 100 ul
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Goat Milk Proteins Antigen Concentrate by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Control Antigen

F247 50 ul
EUR 257
  • Product category: Quality control/standard for molecular biology applications
Description: Goat Milk Proteins Control Antigen by Cygnus Technologies is available in Europe via Gentaur.

Total Goat Milk Proteins ELISA kit

F240 1 kit (96 wells plate)
EUR 1080
  • Product category: Enzyme linked immunosorbent assay (ELISA) kit.
Description: Total Goat Milk Proteins ELISA kit by Cygnus Technologies is available in Europe via Gentaur.

Total Goat Milk Proteins WB kit

F245 1 kit (application dependant amount of reactions)
EUR 836
  • Product category: Premade blotting kit
Description: Total Goat Milk Proteins WB kit by Cygnus Technologies is available in Europe via Gentaur.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-milk fat globulin antibody

STJ16100177 100 µg
EUR 406

Human milk specific allergen antibody(IgE) ELISA Kit

CSB-E15859h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human milk specific allergen antibody (IgE) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human milk specific allergen antibody(IgE) ELISA Kit

1-CSB-E15859h
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human milk specific allergen antibody(IgE) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Anti-Goat Milk Proteins:HRP Conjugate

F241 12 ml
EUR 488
  • Product category: Antibodies
Description: Anti-Goat Milk Proteins:HRP Conjugate by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04 1 ml
EUR 334
  • Product category: Antibodies
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04-AF 1 mg
EUR 1913
  • Product category: Antibodies
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04-PA 1 ml
EUR 488
  • Product category: Antibodies
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04AF-HRP 100 ul
EUR 989
  • Product category: Antibodies
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Skim Milk

abx082021-100g 100 g
EUR 217
  • Shipped within 5-10 working days.

anti-Human Milk Fat Globule 1

YF-PA13135 50 ug
EUR 363
Description: Mouse polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA13136 100 ul
EUR 403
Description: Rabbit polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA13137 100 ug
EUR 403
Description: Rabbit polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA24148 50 ul
EUR 334
Description: Mouse polyclonal to Human Milk Fat Globule 1

Anti-Human Milk Fat Globule 1/MFGE8 Antibody

PA1945 100ug/vial
EUR 334

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Lys proteins Antibody

DF2705 200ul
EUR 304
Description: Lys proteins antibody detects endogenous levels of total Lys proteins.

Lys proteins Antibody

abx219526-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Lys proteins Antibody

ABD2705 100 ug
EUR 438

anti- OCT2-Specific antibody

FNab05962 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: POU class 2 homeobox 2
  • Uniprot ID: P09086
  • Gene ID: 5452
  • Research Area: Cancer, Immunology, Metabolism, Developmental biology
Description: Antibody raised against OCT2-Specific

anti- Oct6-Specific antibody

FNab05965 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: POU class 3 homeobox 1
  • Uniprot ID: Q86VW1
  • Research Area: Neuroscience, Metabolism, Developmental biology
Description: Antibody raised against Oct6-Specific

anti- ORM2-Specific antibody

FNab06014 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:5000
  • IF: 1:50-1:500
  • Immunogen: orosomucoid 2
  • Uniprot ID: P19652
  • Research Area: Cardiovascular
Description: Antibody raised against ORM2-Specific

anti- PACS2-Specific antibody

FNab06099 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • IF: 1:10-1:100
  • Immunogen: phosphofurin acidic cluster sorting protein 2
  • Uniprot ID: Q86VP3
  • Research Area: Cell Division and Proliferation
Description: Antibody raised against PACS2-Specific

anti- Palladin-Specific antibody

FNab06127 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:200-1:1000
  • Immunogen: palladin, cytoskeletal associated protein
  • Uniprot ID: Q8WX93
  • Research Area: Neuroscience, Immunology
Description: Antibody raised against Palladin-Specific

anti- PAX1-Specific antibody

FNab06167 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: paired box 1
  • Uniprot ID: P15863
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against PAX1-Specific

anti- PAX8-Specific antibody

FNab06177 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: paired box 8
  • Uniprot ID: Q06710
  • Research Area: Cancer, Immunology, Metabolism, Developmental biology
Description: Antibody raised against PAX8-Specific

anti- persephin-Specific antibody

FNab06323 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: persephin
  • Uniprot ID: O60542
  • Research Area: Neuroscience, Developmental biology
Description: Antibody raised against persephin-Specific

anti- PFKFB3-Specific antibody

FNab06339 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:50-1:200
  • IF: 1:20-1:200
  • Immunogen: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  • Uniprot ID: Q16875
  • Gene ID: 5209
  • Research Area: Metabolism
Description: Antibody raised against PFKFB3-Specific

anti- PKM1-specific antibody

FNab06494 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:500-1:2000
  • IHC: 1:100-1:400
  • IF: 1:20-1:200
  • Immunogen: PKM2 pyruvate kinase, muscle
  • Uniprot ID: P14618
  • Research Area: Stem Cells, Cancer, Cardiovascular, Metabolism
Description: Antibody raised against PKM1-specific

anti- PKM2-specific antibody

FNab06495 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000-1:4000
  • IP: 1:200-1:1000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • Immunogen: PKM2 pyruvate kinase, muscle
  • Uniprot ID: P14618
  • Research Area: Stem Cells, Cancer, Cardiovascular, Metabolism
Description: Antibody raised against PKM2-specific

anti- PKM2-specific antibody

FNab06496 100µg
EUR 548.75
  • Recommended dilution: WB: 1:2000-1:16000
  • IP: 1:200-1:1000
  • IHC: 1:100-1:1000
  • IF: 1:20-1:200
  • Immunogen: PKM2 pyruvate kinase, muscle
  • Uniprot ID: P14618
  • Research Area: Stem Cells, Cancer, Cardiovascular, Metabolism
Description: Antibody raised against PKM2-specific

anti- PLOD2-Specific antibody

FNab06552 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:200-1:1000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • Immunogen: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
  • Uniprot ID: O00469
  • Research Area: Metabolism
Description: Antibody raised against PLOD2-Specific

anti- POLR2B-Specific antibody

FNab06620 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:5000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: polymerase(RNA) II(DNA directed) polypeptide B, 140kDa
  • Uniprot ID: P30876
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against POLR2B-Specific

anti- POTEA-Specific antibody

FNab06647 100µg
EUR 585
  • Recommended dilution: IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: POTE ankyrin domain family, member A
  • Uniprot ID: Q6S8J7
  • Research Area: Cell Division and Proliferation
Description: Antibody raised against POTEA-Specific

anti- POTED-Specific antibody

FNab06648 100µg
EUR 585
  • Recommended dilution: WB 1:500-1:1000
  • IHC 1:50-1:100
  • Immunogen: POTE ankyrin domain family, member D
  • Uniprot ID: Q86YR6
  • Gene ID: 317754
  • Research Area: Cell Division and Proliferation
Description: Antibody raised against POTED-Specific

anti- POU3F3-Specific antibody

FNab06651 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • Immunogen: POU class 3 homeobox 3
  • Uniprot ID: P20264
  • Research Area: Neuroscience, Metabolism, Developmental biology
Description: Antibody raised against POU3F3-Specific

anti- PPIF-Specific antibody

FNab06676 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • IP: 1:500-1:2000
  • Immunogen: peptidylprolyl isomerase F
  • Uniprot ID: P30405
  • Research Area: Metabolism
Description: Antibody raised against PPIF-Specific

anti- PPP1CB-Specific antibody

FNab06695 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • IP: 1:500-1:2000
  • Immunogen: protein phosphatase 1, catalytic subunit, beta isoform
  • Uniprot ID: P62140
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against PPP1CB-Specific

anti- PPP1R11-Specific antibody

FNab06699 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: protein phosphatase 1, regulatory(inhibitor) subunit 11
  • Uniprot ID: O60927
  • Research Area: Metabolism
Description: Antibody raised against PPP1R11-Specific

anti- PSEN2-Specific antibody

FNab06853 100µg
EUR 548.75
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: presenilin 2(Alzheimer disease 4)
  • Uniprot ID: P49810
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Immunology, Neuroscience
Description: Antibody raised against PSEN2-Specific

anti- PTH-Specific antibody

FNab06923 100µg
EUR 585
  • Recommended dilution: WB: 1:1000-1:4000
  • Immunogen: parathyroid hormone
  • Uniprot ID: P01270
  • Gene ID: 5741
  • Research Area: Cancer, Immunology, Signal Transduction, Developmental biology
Description: Antibody raised against PTH-Specific

anti- PYGM-Specific antibody

FNab06977 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: phosphorylase, glycogen, muscle
  • Uniprot ID: P11217
  • Gene ID: 5837
  • Research Area: Metabolism
Description: Antibody raised against PYGM-Specific

anti- RAB11B-Specific antibody

FNab06989 100µg
EUR 505.25
  • Recommended dilution: WB: 1:300-1:600
  • IHC: 1:20-1:200
  • Immunogen: RAB11B, member RAS oncogene family
  • Uniprot ID: Q15907
  • Gene ID: 9230
  • Research Area: Signal Transduction
Description: Antibody raised against RAB11B-Specific

anti- RAB11-Specific antibody

FNab06994 100µg
EUR 505.25
  • Immunogen: RAB11A, member RAS oncogene family
  • Uniprot ID: P62491
  • Research Area: Signal Transduction
Description: Antibody raised against RAB11-Specific

anti- RAB22A-specific antibody

FNab07005 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: RAB22A, member RAS oncogene family
  • Uniprot ID: Q9UL26
  • Research Area: Signal Transduction
Description: Antibody raised against RAB22A-specific

anti- RAB27A-specific antibody

FNab07011 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: RAB27A, member RAS oncogene family
  • Uniprot ID: P51159
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against RAB27A-specific

anti- RAB31-specific antibody

FNab07015 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: RAB31, member RAS oncogene family
  • Uniprot ID: Q13636
  • Research Area: Signal Transduction
Description: Antibody raised against RAB31-specific

anti- RAB3A-specific antibody

FNab07025 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:50-1:500
  • IF: 1:10-1:100
  • Immunogen: RAB3A, member RAS oncogene family
  • Uniprot ID: P20336
  • Research Area: Signal Transduction
Description: Antibody raised against RAB3A-specific

anti- RAB3C-specific antibody

FNab07028 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IF: 1:10-1:100
  • Immunogen: RAB3C, member RAS oncogene family
  • Uniprot ID: Q96E17
  • Research Area: Signal Transduction
Description: Antibody raised against RAB3C-specific

anti- RAB5A-Specific antibody

FNab07039 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:50-1:500
  • Immunogen: RAB5A, member RAS oncogene family
  • Uniprot ID: P20339
  • Gene ID: 5868
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against RAB5A-Specific

anti- RAB9A-Specific antibody

FNab07049 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: RAB9A, member RAS oncogene family
  • Research Area: Signal Transduction
Description: Antibody raised against RAB9A-Specific

anti- REDD1 specific antibody

FNab07228 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IP: 1:200-1:2000
  • IHC: 1:50-1:200
  • Immunogen: DNA-damage-inducible transcript 4
  • Uniprot ID: Q9NX09
  • Gene ID: 54541
  • Research Area: Epigenetics, Immunology, Cardiovascular
Description: Antibody raised against REDD1 specific

anti- RIM2-Specific antibody

FNab07301 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: regulating synaptic membrane exocytosis 2
  • Uniprot ID: Q9UQ26
  • Research Area: Neuroscience
Description: Antibody raised against RIM2-Specific

anti- RIMS4-Specific antibody

FNab07305 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: regulating synaptic membrane exocytosis 4
  • Uniprot ID: Q9H426
  • Research Area: Neuroscience
Description: Antibody raised against RIMS4-Specific

anti- RIPK1-Specific antibody

FNab07313 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IP: 1:200-1:1000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • Immunogen: receptor(TNFRSF)-interacting serine-threonine kinase 1
  • Uniprot ID: Q13546
  • Research Area: Immunology, Signal Transduction, Metabolism
Description: Antibody raised against RIPK1-Specific

anti- ROBO1-Specific antibody

FNab07372 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: roundabout, axon guidance receptor, homolog 1(Drosophila)
  • Uniprot ID: Q9Y6N7
  • Research Area: Neuroscience, Immunology, Cardiovascular, Developmental biology
Description: Antibody raised against ROBO1-Specific

anti- ROBO3-Specific antibody

FNab07374 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: roundabout, axon guidance receptor, homolog 3(Drosophila)
  • Uniprot ID: Q96MS0
  • Research Area: Neuroscience, Stem Cells, Cardiovascular, Developmental biology
Description: Antibody raised against ROBO3-Specific

anti- ROBO4-Specific antibody

FNab07375 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: roundabout homolog 4, magic roundabout(Drosophila)
  • Uniprot ID: Q8WZ75
  • Research Area: Immunology, Cardiovascular, Developmental biology
Description: Antibody raised against ROBO4-Specific

anti- ROCK1-Specific antibody

FNab07377 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:20-1:200
  • Immunogen: Rho-associated, coiled-coil containing protein kinase 1
  • Uniprot ID: Q13464
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Cell Division
  • Show more
Description: Antibody raised against ROCK1-Specific

anti- ROCK2-Specific antibody

FNab07379 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: Rho-associated, coiled-coil containing protein kinase 2
  • Uniprot ID: O75116
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biolog
  • Show more
Description: Antibody raised against ROCK2-Specific

anti- RRM1-Specific antibody

FNab07495 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IF: 1:10-1:100
  • Immunogen: ribonucleotide reductase M1
  • Uniprot ID: P23921
  • Gene ID: 6240
  • Research Area: Cancer, Immunology, Metabolism
Description: Antibody raised against RRM1-Specific

anti- RtcB-Specific antibody

FNab07515 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000-1:4000
  • IP: 1:500-1:1000
  • IF: 1:10-1:100
  • Immunogen: chromosome 22 open reading frame 28
  • Uniprot ID: Q9Y3I0
Description: Antibody raised against RtcB-Specific

anti- SEC61B-Specific antibody

FNab07691 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000-1:4000
  • IF: 1:20-1:200
  • IHC: 1:20-1:200
  • Immunogen: Sec61 beta subunit
  • Uniprot ID: P60468
  • Research Area: Metabolism
Description: Antibody raised against SEC61B-Specific

anti- SENP5-Specific antibody

FNab07714 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: SUMO1/sentrin specific peptidase 5
  • Uniprot ID: Q96HI0
  • Research Area: Metabolism
Description: Antibody raised against SENP5-Specific

anti- SERINC2-Specific antibody

FNab07736 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: serine incorporator 2
  • Uniprot ID: Q96SA4
  • Research Area: Metabolism
Description: Antibody raised against SERINC2-Specific

anti- SIRT2-Specific antibody

FNab07880 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: sirtuin(silent mating type information regulation 2 homolog) 2(S. cerevisiae)
  • Uniprot ID: Q8IXJ6
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against SIRT2-Specific

anti- SLC12A5-Specific antibody

FNab07908 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • Immunogen: solute carrier family 12(potassium-chloride transporter), member 5
  • Uniprot ID: Q9H2X9
  • Research Area: Signal Transduction
Description: Antibody raised against SLC12A5-Specific

anti- SLC25A6-Specific antibody

FNab07947 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: solute carrier family 25(mitochondrial carrier
  • adenine nucleotide translocator), member 6
  • Uniprot ID: P12236
  • Research Area: Metabolism
Description: Antibody raised against SLC25A6-Specific

anti- SMYD1-Specific antibody

FNab08047 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: SET and MYND domain containing 1
  • Uniprot ID: Q8NB12
  • Research Area: Metabolism
Description: Antibody raised against SMYD1-Specific

anti- Somatostatin-Specific antibody

FNab08109 100µg
EUR 548.75
  • Recommended dilution: IHC: 1:4000-1:16000
  • Immunogen: somatostatin
  • Uniprot ID: P61278
  • Research Area: Signal Transduction, Metabolism, Immunology, Cancer, Neuroscience, Stem Cells
Description: Antibody raised against Somatostatin-Specific

anti- SPAG4-Specific antibody

FNab08142 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: sperm associated antigen 4
  • Uniprot ID: Q9NPE6
  • Research Area: Developmental biology
Description: Antibody raised against SPAG4-Specific

anti- SPIN1-Specific antibody

FNab08178 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: spindlin 1
  • Uniprot ID: Q9Y657
  • Research Area: Developmental biology
Description: Antibody raised against SPIN1-Specific

anti- SPTBN1-Specific antibody

FNab08204 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IP:1:200-1:2000
  • IHC: 1:20-1:200
  • Immunogen: spectrin, beta, non-erythrocytic 1
  • Uniprot ID: Q01082
  • Research Area: Signal Transduction
Description: Antibody raised against SPTBN1-Specific

anti- SRGAP3-Specific antibody

FNab08227 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: SLIT-ROBO Rho GTPase activating protein 3
  • Uniprot ID: O43295
  • Research Area: Signal Transduction
Description: Antibody raised against SRGAP3-Specific

anti- ST8SIA2-Specific antibody

FNab08276 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
  • Uniprot ID: Q92186
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against ST8SIA2-Specific

anti- STEAP2-Specific antibody

FNab08317 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: six transmembrane epithelial antigen of the prostate 2
  • Uniprot ID: Q8NFT2
  • Research Area: Metabolism
Description: Antibody raised against STEAP2-Specific

anti- SYN1-Specific antibody

FNab08416 100µg
EUR 548.75
  • Recommended dilution: WB: 1:2000-1:20000
  • IP: 1:1000-1:10000
  • Immunogen: synapsin I
  • Uniprot ID: P17600
  • Research Area: Neuroscience, Metabolism
Description: Antibody raised against SYN1-Specific

anti- TAF1-Specific antibody

FNab08484 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:20-1:200
  • Immunogen: TAF1 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 250kDa
  • Uniprot ID: P21675
  • Research Area: Metabolism
Description: Antibody raised against TAF1-Specific

anti- TDRKH specific antibody

FNab08580 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:3000
  • IP: 1:200-1:1400
  • IHC: 1:50-1:500
  • IF: 1:50-1:500
  • Immunogen: tudor and KH domain containing
  • Uniprot ID: Q9Y2W6
  • Research Area: Metabolism
Description: Antibody raised against TDRKH specific

anti- TGFBR3-Specific antibody

FNab08645 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: transforming growth factor, beta receptor III
  • Uniprot ID: Q03167
  • Research Area: Immunology, Cardiovascular, Developmental biology, Signal Transduction
Description: Antibody raised against TGFBR3-Specific

anti- TINAG-Specific antibody

FNab08712 100µg
EUR 585
  • Recommended dilution: WB: 1:500 - 1:3000
  • IHC: 1:20 - 1:200
  • Immunogen: tubulointerstitial nephritis antigen
  • Uniprot ID: Q9UJW2
  • Research Area: Cardiovascular, Metabolism
Description: Antibody raised against TINAG-Specific

anti- TMF1-Specific antibody

FNab08796 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: TATA element modulatory factor 1
  • Uniprot ID: P82094
  • Research Area: Metabolism
Description: Antibody raised against TMF1-Specific

anti- TOP2A-Specific antibody

FNab08868 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:3000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: topoisomerase(DNA) II alpha 170kDa
  • Uniprot ID: P11388
  • Research Area: Epigenetics, Cell Division and Proliferation, Metabolism
Description: Antibody raised against TOP2A-Specific

anti- GAB3-Specific antibody

FNab03273 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: GRB2-associated binding protein 3
  • Uniprot ID: Q8WWW8
  • Research Area: Signal Transduction, Developmental biology
Description: Antibody raised against GAB3-Specific

anti- GABARAPL1-Specific antibody

FNab03276 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: GABA(A) receptor-associated protein like 1
  • Uniprot ID: Q9H0R8
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against GABARAPL1-Specific

anti- GABARAPL2-Specific antibody

FNab03278 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: GABA(A) receptor-associated protein-like 2
  • Uniprot ID: P60520
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against GABARAPL2-Specific

anti- GAC-specific antibody

FNab03290 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:100-1:400
  • Immunogen: glutaminase
  • Uniprot ID: O94925
  • Research Area: Neuroscience, Metabolism
Description: Antibody raised against GAC-specific

anti- GATA4-Specific antibody

FNab03363 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: GATA binding protein 4
  • Uniprot ID: P43694
  • Gene ID: 2626
  • Research Area: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Stem Cell
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Description: Antibody raised against GATA4-Specific
These findings steered that AWLNH and PHDL can stimulate osteoblast differentiation of hBMMSCs through upregulating the canonical Wnt/β-catenin signaling and could also be helpful for a possible nutraceuticals or prescribed drugs to deal with osteoporosis. PRACTICAL APPLICATIONS: Ark shell is a well-liked foodstuff in Korea. However, organic results of its protein and peptide haven’t been explored in some ways. This examine demonstrated that ark shell protein-derived peptides promoted osteoblast differentiation in hBMMSCs by means of upregulating the canonical Wnt/β-catenin signaling. The outcomes of this examine might be a foundation to advertise its utility as practical meals and/or nutraceuticals.