Aberrant activation of Wnt/β-catenin signaling pathway, due to the genetic or epigenetic modifications, is chargeable for tumorigenesis in epithelial cells of differing types of most cancers akin to colorectal most cancers. Secreted Frizzled-Related Protein-1 (SFRP1), as one of the antagonist proteins of this pathway, is hyper-methylated in colorectal most cancers main to the formation of Wnt-Fz-LRP and activation of Wnt/β-catenin signaling pathway. We aimed to design antagonist peptides based on SFRP1 structure in opposition to wingless-type 2 (Wnt2), a extremely expressed ligand in numerous cancers like colorectal most cancers, to inhibit the formation of the preliminary triple complicated of Wnt-Fz-LRP. After homology modeling of SFRP1, molecular docking confirmed that Wnt2 and SFRP1 work together in the identical mode of xWnt8-mFzEight and hWnt3-mFzEight by way of the thumb and finger binding websites.
These binding websites had been chosen for designing peptides utilizing both substitution or deep learning-based approaches. The effectivity of every designed peptide in interacting with Wnt2 was evaluated by molecular docking. Stability evaluation of Wnt2-peptide complexes by way of molecular dynamic (MD) revealed that the designed peptides may successfully work together with Wnt2 binding websites throughout the simulation. However, the designed peptides in opposition to the thumb website had greater binding affinity and hydrogen bonds in contrast to the preliminary sequence. The secondary structure of the designed peptides indicated an alpha-helix structure which is a good structure for peptide medication. Computing the physicochemical properties of peptides predicted a reasonably acceptable structure which made them promising candidates in the remedy of cancers like CRC.
Secreted frizzled-related protein 2: a key participant in noncanonical Wnt signaling and tumor angiogenesis
Secreted frizzled-related proteins (SFRP) are glycoproteins containing a so-called frizzled-like cysteine-rich area. This area permits them to bind to Wnt ligands or frizzled (FzD) receptors, making potent regulators of Wnt signaling. As Wnt signaling is usually altered in most cancers, it isn’t shocking that Wnt regulators akin to SFRP proteins are sometimes differentially expressed in the tumor microenvironment, each in a metastatic and non-metastatic setting. Indeed, SFRP2 is proven to be particularly upregulated in the tumor vasculature of a number of varieties of most cancers. Several research investigated the purposeful position of SFRP2 in the tumor vasculature, displaying that SFRP2 binds to FzD receptors on the floor of tumor endothelial cells. This prompts downstream Wnt signaling and which is, thereby, stimulating angiogenesis. Interestingly, not the well-known canonical Wnt signaling pathway, however the noncanonical Wnt/Ca2+ pathway appears to be a key participant on this occasion.
In tumor fashions, the pro-angiogenic impact of SFRP2 could possibly be counteracted by antibodies concentrating on SFRP2, with out the incidence of toxicity. Since tumor angiogenesis is a vital course of in tumorigenesis and metastasis formation, particular tumor endothelial markers akin to SFRP2 present nice promise as targets for anti-cancer therapies. This overview discusses the position of SFRP2 in noncanonical Wnt signaling and tumor angiogenesis, and highlights its potential as anti-angiogenic therapeutic goal in most cancers. Haemophilus parasuis induces extreme acute systemic an infection in pigs, characterised by fibrinous polyserositis, polyarthritis and meningitis. Our earlier examine demonstrated that H. parasuis induced the activation of p38 mitogen-activated protein kinase (MAPK) pathway, rising the expression of proinflammatory genes and mediating H. parasuis-induced irritation. Moreover, Wnt/β-catenin signaling activation induced by H. parasuis disrupts the adherens junction between epithelial cells and initiates the epithelial-mesenchymal transition (EMT).
In the current examine, p38 MAPK was discovered to be concerned in the accumulation of nuclear location of β-catenin throughout H. parasuis an infection in PK-15 and NPTr cells, by way of modulating the expression of dickkofp-1 (DKK-1), a damaging regulator of Wnt/β-catenin signaling. We generated DKK-1 knockout cell strains by CRISPR/Cas9-mediated genome enhancing in PK-15 and NPTr cells, and located that knockout of DKK-1 led to the dysfunction of p38 MAPK in regulating Wnt/β-catenin signaling exercise in H. parasuis-infected cells. Furthermore, p38 MAPK exercise was impartial of the activation of Wnt/β-catenin signaling throughout H. parasuis an infection. This is the first examine to discover the crosstalk between p38 MAPK and Wnt/β-catenin signaling throughout H. parasuis an infection. It supplies a extra complete view of intracellular signaling pathways throughout pathogenic bacteria-induced acute irritation.

Computational design of antagonist peptides based on the structure of secreted frizzled-related protein-1 (SFRP1) aiming to inhibit Wnt signaling pathway
Inhibition of protein tyrosine phosphatase receptor sort F suppresses Wnt signaling in colorectal most cancers
Wnt signaling dysregulation promotes tumorigenesis in colorectal most cancers (CRC). We investigated the position of PTPRF, a receptor-type tyrosine phosphatase, in regulating Wnt signaling in CRC. Knockdown of PTPRF decreased cell proliferation in patient-derived main colon most cancers cells and established CRC cell strains. In addition, the charge of proliferation in addition to colony formation skill had been considerably decreased in tumor organoids grown in 3D, whereas the quantity of differentiated tumor organoids had been markedly elevated. Consistently, knockdown of PTPRF resulted in a lower in the expression of genes related to most cancers stem cells downstream of Wnt/β-catenin signaling.
Active AHCY, human recombinant |
7527-50 |
Biovision |
|
EUR 479 |
Active Recombinant Human CETP |
7606-100 |
Biovision |
|
EUR 805 |
Active Recombinant Human CETP |
7606-1000 |
Biovision |
|
EUR 4345 |
Active Recombinant Human CETP |
7606-20 |
Biovision |
|
EUR 262 |
Active SIRT2, human recombinant |
7698-10 |
Biovision |
|
EUR 262 |
Active SIRT2, human recombinant |
7698-1000 |
Biovision |
|
EUR 4394 |
Active SIRT2, human recombinant |
7698-50 |
Biovision |
|
EUR 457 |
Active SIRT7, human recombinant |
7846-10 |
Biovision |
|
EUR 218 |
Active SIRT7, human recombinant |
7846-50 |
Biovision |
|
EUR 588 |
Irisin, Active, human recombinant |
7852-10 |
Biovision |
|
EUR 370 |
Irisin, Active, human recombinant |
7852-50 |
Biovision |
|
EUR 1077 |
HER2, Active, Human Recombinant |
8011-5 |
Biovision |
|
EUR 240 |
HER2, Active, Human Recombinant |
8011-50 |
Biovision |
|
EUR 1132 |
PRMT1, human recombinant (Active) |
4865-10 |
Biovision |
|
EUR 153 |
PRMT1, human recombinant (Active) |
4865-1000 |
Biovision |
|
EUR 3834 |
PRMT1, human recombinant (Active) |
4865-50 |
Biovision |
|
EUR 392 |
GAPDH, Active, human recombinant |
P1100-10 |
Biovision |
|
EUR 142 |
GAPDH, Active, human recombinant |
P1100-50 |
Biovision |
|
EUR 392 |
Active Cathepsin S, human recombinant |
7526-10 |
Biovision |
|
EUR 338 |
Active Cathepsin S, human recombinant |
7526-50 |
Biovision |
|
EUR 1126 |
Active Cathepsin S, human recombinant |
7526-500 |
Biovision |
|
EUR 9130 |
Active Cathepsin B, human recombinant |
7580-1000 |
Biovision |
|
EUR 9783 |
Active Cathepsin B, human recombinant |
7580-5 |
Biovision |
|
EUR 294 |
Active Cathepsin B, human recombinant |
7580-50 |
Biovision |
|
EUR 1132 |
Cathepsin K, Active, human recombinant |
7600-5 |
Biovision |
|
EUR 392 |
Cathepsin K, Active, human recombinant |
7600-50 |
Biovision |
|
EUR 2279 |
MMP-9, Active, human recombinant |
7867-1000 |
Biovision |
|
EUR 501 |
MMP-9, Active, human recombinant |
7867-500 |
Biovision |
|
EUR 332 |
Active BCL2L1 Protein, human recombinant |
7885-10 |
Biovision |
|
EUR 256 |
Active BCL2L1 Protein, human recombinant |
7885-50 |
Biovision |
|
EUR 691 |
MMP-14, Active, Human Recombinant |
8009-10 |
Biovision |
|
EUR 316 |
MMP-14, Active, Human Recombinant |
8009-50 |
Biovision |
|
EUR 805 |
Active Cathepsin D, Human Recombinant |
9229-10 |
Biovision |
|
EUR 245 |
Active Cathepsin D, Human Recombinant |
9229-100 |
Biovision |
|
EUR 1132 |
Active Cathepsin D, Human Recombinant |
9229-50 |
Biovision |
|
EUR 735 |
MMP-9, Active, Human Recombinant |
P1567-10 |
Biovision |
10 µg |
EUR 348 |
MMP-9, Active, Human Recombinant |
P1567-50 |
Biovision |
50 µg |
EUR 510 |
5-Lipoxygenase, Active, Human Recombinant |
P1373-200 |
Biovision |
|
EUR 316 |
Recombinant Human Activin-A Active |
7-00004 |
CHI Scientific |
1ug |
Ask for price |
Recombinant Human Activin-A Active |
7-00005 |
CHI Scientific |
5ug |
Ask for price |
Recombinant Human Activin-A Active |
7-00006 |
CHI Scientific |
100µg |
Ask for price |
Recombinant Human Activin-B Active |
7-00010 |
CHI Scientific |
1ug |
Ask for price |
Recombinant Human Activin-B Active |
7-00011 |
CHI Scientific |
5ug |
Ask for price |
Recombinant Human Activin-B Active |
7-00012 |
CHI Scientific |
100µg |
Ask for price |
Human CellExp? HDAC6, Human Recombinant, Active |
P1265-50 |
Biovision |
|
EUR 446 |
Human CellExp? HDAC8, Human Recombinant, Active |
P1266-50 |
Biovision |
|
EUR 446 |
Human CellExp? HDAC11, Human Recombinant, Active |
P1267-50 |
Biovision |
|
EUR 446 |
PRMT1, mouse recombinant (Active) |
4868-10 |
Biovision |
|
EUR 153 |
PRMT1, mouse recombinant (Active) |
4868-1000 |
Biovision |
|
EUR 3834 |
PRMT1, mouse recombinant (Active) |
4868-50 |
Biovision |
|
EUR 392 |
Active SIRT6 (GST-tagged), human recombinant |
7697-100 |
Biovision |
|
EUR 479 |
Active SIRT6 (GST-tagged), human recombinant |
7697-1000 |
Biovision |
|
EUR 3013 |
Active SIRT6 (GST-tagged), human recombinant |
7697-20 |
Biovision |
|
EUR 272 |
Active SIRT6 (His-tagged), human recombinant |
7699-100 |
Biovision |
|
EUR 425 |
Active SIRT6 (His-tagged), human recombinant |
7699-1000 |
Biovision |
|
EUR 2545 |
Active SIRT6 (His-tagged), human recombinant |
7699-20 |
Biovision |
|
EUR 218 |
Active Sonic Hedgehog (SHH), human recombinant |
4010-100 |
Biovision |
|
EUR 936 |
Active Sonic Hedgehog (SHH), human recombinant |
4010-1000 |
Biovision |
|
EUR 4432 |
Active Sonic Hedgehog (SHH), human recombinant |
4010-25 |
Biovision |
|
EUR 327 |
Activin-A Human Recombinant Protein, Active |
PROTP08476-2 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Active form Activin-A Human Recombinant produced in e.coli is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 117 amino acids and having a molecular weight of 26.2kDa.;The Active form Activin-A is purified by standard chromatographic techniques. |
Activin-B Human Recombinant Protein, Active |
PROTP09529 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques. |
Recombinant Human Active Focal Adhesion Kinase |
7-03955 |
CHI Scientific |
1µg |
Ask for price |
Recombinant Human Active Focal Adhesion Kinase |
7-03956 |
CHI Scientific |
5µg |
Ask for price |
Recombinant Human Active Focal Adhesion Kinase |
7-03957 |
CHI Scientific |
10µg |
Ask for price |
Recombinant Human Alpha-1 Antitrypsin, Active |
7-06361 |
CHI Scientific |
20µg |
Ask for price |
Recombinant Human Alpha-1 Antitrypsin, Active |
7-06362 |
CHI Scientific |
100µg |
Ask for price |
Recombinant Human Alpha-1 Antitrypsin, Active |
7-06363 |
CHI Scientific |
1mg |
Ask for price |
Active Human Caspases Group I, Active Human |
K241-3-25 |
Biovision |
|
EUR 370 |
Oxalate Decarboxylase, Active Bacterial Recombinant |
7262-100 |
Biovision |
|
EUR 446 |
Oxalate Decarboxylase, Active Bacterial Recombinant |
7262-1000 |
Biovision |
|
EUR 2931 |
Oxalate Decarboxylase, Active Bacterial Recombinant |
7262-20 |
Biovision |
|
EUR 245 |
Active Caspase-1, rat recombinant |
7524-100 |
Biovision |
|
EUR 555 |
Active Caspase-1, rat recombinant |
7524-25 |
Biovision |
|
EUR 338 |
Cathepsin K, Active, mouse recombinant |
7597-5 |
Biovision |
|
EUR 359 |
Cathepsin K, Active, mouse recombinant |
7597-50 |
Biovision |
|
EUR 2170 |
Cathepsin K, Active, rat recombinant |
7598-5 |
Biovision |
|
EUR 359 |
Cathepsin K, Active, rat recombinant |
7598-50 |
Biovision |
|
EUR 2170 |
Aprotinin, Active, Bovine Recombinant (AOF) |
7866-1 |
Biovision |
|
EUR 115 |
Aprotinin, Active, Bovine Recombinant (AOF) |
7866-5 |
Biovision |
|
EUR 158 |
Active HRV14 3C Protease Recombinant |
8012-100 |
Biovision |
|
EUR 588 |
Active HRV14 3C Protease Recombinant |
8012-20 |
Biovision |
|
EUR 207 |
PDK, Active, M. rosea Recombinant |
P1161-50 |
Biovision |
|
EUR 398 |
D-Serine Dehydratase, Active, Recombinant |
P1193-200 |
Biovision |
|
EUR 457 |
D-Serine Dehydratase, Active, Recombinant |
P1193-600 |
Biovision |
|
EUR 914 |
Homocysteine ?,?-Lyase (rHCYase), Active, Recombinant |
P1117-200 |
Biovision |
|
EUR 425 |
Recombinant WNV Active E Antigen |
VAng-Lsx0573-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: WNV Active E Antigen, recombinant protein from E. coli. |
Recombinant MeV Active Nucleocapsid Protein |
VAng-Lsx0400-inquire |
Creative Biolabs |
inquire |
Ask for price |
Description: Measles Active Nucleocapsid, recombinant protein from E. coli. |
Active Transglutaminase 2 (His-tagged), human recombinant |
7700-10 |
Biovision |
|
EUR 233 |
Active Transglutaminase 2 (His-tagged), human recombinant |
7700-100 |
Biovision |
|
EUR 592 |
Fructose 1,6-bisphophatase 1, Active, Human Recombinant |
P1269-10 |
Biovision |
|
EUR 153 |
Fructose 1,6-bisphophatase 1, Active, Human Recombinant |
P1269-50 |
Biovision |
|
EUR 479 |
Thioredoxin isoform 1 (Trx), Active, Human Recombinant |
P1039-100 |
Biovision |
|
EUR 240 |
Activin-A Human Recombinant Protein, Plant-Active |
PROTP08476-3 |
BosterBio |
Regular: 5ug |
EUR 317 |
Description: Active form Activin-A Human Recombinant produced in Plant is a homodimeric, glycosylated, polypeptide chain containing 2 x 116 amino acids and having a molecular weight of 27.4kDa.;The Active form Activin-A is fused to a 6-His tag at N-terminus and purified by standard chromatographic techniques. |
Recombinant Human Casein Kinase 2 beta Active |
7-03892 |
CHI Scientific |
3µg |
Ask for price |
Recombinant Human Casein Kinase 2 beta Active |
7-03893 |
CHI Scientific |
10µg |
Ask for price |
Recombinant Human Casein Kinase 2 beta Active |
7-03894 |
CHI Scientific |
20µg |
Ask for price |
Purified Recombinant Human BMP3 protein, Biologically active |
BMP35-R-10 |
Alpha Diagnostics |
10 ug |
EUR 408 |
Purified Recombinant Human BMP4 protein, Biologically active, |
BMP45-R-10 |
Alpha Diagnostics |
10 ug |
EUR 895 |
Purified Recombinant Human BMP4 protein, Biologically active |
BMP45-R-5 |
Alpha Diagnostics |
5 ug |
EUR 529 |
Purified Recombinant Human BMP6 protein, Biologically active |
BMP65-R-20 |
Alpha Diagnostics |
20 ug |
EUR 895 |
Recombinant purified, human NFkB-p65 protein, active |
NFKB651-R-5 |
Alpha Diagnostics |
5 ug |
EUR 651 |
Recombinant (E.Coli) Human ERK1/MAPK3 Active Enzyme |
RP-670 |
Alpha Diagnostics |
3 ug |
EUR 590 |
Recombinant (E.Coli) Human ERK2/MAPK1 Active Enzyme |
RP-672 |
Alpha Diagnostics |
1 ug |
EUR 590 |
Purified, recombinant Human TACE control protein (active) |
TACE15-R-10 |
Alpha Diagnostics |
10 ug |
EUR 712 |
Human Recombinant VEGF121 Protein (Sf9), biologically active |
VEGF24-R-10 |
Alpha Diagnostics |
10 ug |
EUR 445 |
Human Recombinant VEGF121 Protein (Sf9), biologically active |
VEGF24-R-100 |
Alpha Diagnostics |
100 ug |
EUR 2425 |
Human Recombinant VEGF121 Protein (E.Coli), biologically active |
VEGF25-R-10 |
Alpha Diagnostics |
10 ug |
EUR 445 |
Human Recombinant VEGF121 Protein (E.Coli), biologically active |
VEGF25-R-100 |
Alpha Diagnostics |
100 ug |
EUR 2425 |
Human Recombinant VEGF165 Protein (E.Coli), biologically active |
VEGF26-R-10 |
Alpha Diagnostics |
10 ug |
EUR 445 |
Human Recombinant VEGF165 Protein (E.Coli), biologically active |
VEGF26-R-100 |
Alpha Diagnostics |
100 ug |
EUR 2242 |
Human Recombinant VEGF165 Protein (E.Coli), biologically active |
VEGF26-R-1000 |
Alpha Diagnostics |
1000 ug |
EUR 9185 |
Human Recombinant VEGF165 Protein (Sf9), biologically active |
VEGF27-R-10 |
Alpha Diagnostics |
10 ug |
EUR 445 |
Human Recombinant VEGF165 Protein (HEK), biologically active |
VEGF27-R-100 |
Alpha Diagnostics |
100 ug |
EUR 2425 |
Human Recombinant VEGF165 Protein (Sf9), biologically active |
VEGF27-R-1000 |
Alpha Diagnostics |
1000 ug |
EUR 9185 |
Human CellExp? HDAC5, Catalytic Domain, Human Recombinant, Active |
P1268-50 |
Biovision |
|
EUR 446 |
CSTA Human, Cystatin-A Human Recombinant Protein, Active |
PROTP01040 |
BosterBio |
Regular: 20ug |
EUR 317 |
Description: Cystatin A Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain containing 118 amino acids (1-98a.a.) and having a molecular mass of 13.1 kDa.;The Cystatin A is fused to a 20 amino acid His tag at N-terminus and purified by proprietary chromatographic techniques. |
Human, Activin-A Human Recombinant Protein, HEK-Active |
PROTP08476-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Activin-A Human Recombinant produced in HEK cells is a non-glycosylated disulfide-linked homodimer, having a total molecular weight of 25kDa.;The Activin-A is purified by proprietary chromatographic techniques. |
PGP Human, Phosphoglycolate Phosphatase Human Recombinant Protein, Active |
PROTA6NDG6-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: PGP Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 345 amino acids (1-321a.a) and having a molecular mass of 36.5kDa.;PGP is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
GDA Human, Guanine Deaminase Human Recombinant Protein, Active |
PROTQ9Y2T3-2 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: GDA Human Recombinant produced in E. coli is a single polypeptide chain containing 477 amino acids (1-454) and having a molecular mass of 53kDa.;GDA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. |
GLUL Human, Glutamine Synthetase Human Recombinant Protein, Active |
PROTP15104-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: GLUL Recombinant Human produced in E.Coli is a single, non-glycosylated polypeptide chain containing 373 amino acids (1-373) and having a molecular mass of 42kDa. |
GLO1 Human, Glyoxalase-I Human Recombinant Protein, Active |
PROTQ04760-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Glyoxalase-I Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 184 amino acids and having a molecular mass of 20.7 kDa. ;Glyoxalase-1 is purified by proprietary chromatographic techniques. |
CST3 Human, Cystatin-C Human Recombinant Protein, Active |
PROTQ6FGW9-1 |
BosterBio |
Regular: 10ug |
EUR 317 |
Description: Cystatin-C Human Recombinant produced in HEK cells is a non-glycosylated monomer, having a molecular weight of approximately 13kDa.;The Cystatin-C is purified by proprietary chromatographic techniques. |
MGLL Human, Monoglyceride Lipase Human Recombinant Protein, Active |
PROTQ99685-1 |
BosterBio |
Regular: 5ug |
EUR 317 |
Description: MGLL Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 333 amino acids (1-313 a.a.) and having a molecular mass of 36.4kDa. The MGLL is purified by proprietary chromatographic techniques. |
Human Tau proteins ELISA kit |
CSB-E12011h-24T |
Cusabio |
1 plate of 24 wells |
EUR 165 |
|
Description: Quantitativesandwich ELISA kit for measuring Human Tau proteins in samples from serum, plasma, cerebrospinalfluid (CSF). A new trial version of the kit, which allows you to test the kit in your application at a reasonable price. |
Human Tau proteins ELISA kit |
1-CSB-E12011h |
Cusabio |
-
EUR 900.00
-
EUR 5476.00
-
EUR 2900.00
|
-
1 plate of 96 wells
-
10 plates of 96 wells each
-
5 plates of 96 wells each
|
|
Description: Quantitativesandwich ELISA kit for measuring Human Tau proteins in samples from serum, plasma, cerebrospinalfluid(CSF). Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits. |
Lys proteins Antibody |
DF2705 |
Affbiotech |
200ul |
EUR 304 |
Description: Lys proteins antibody detects endogenous levels of total Lys proteins. |
Bone Matrix Proteins |
20-abx265965 |
Abbexa |
-
EUR 384.00
-
EUR 592.00
-
EUR 300.00
|
|
|
Lys proteins Antibody |
abx219526-100ug |
Abbexa |
100 ug |
EUR 439 |
|
Active Recombinant Human beta-Secretase 1 - BACE-1 |
7609-1000 |
Biovision |
|
EUR 9783 |
Active Recombinant Human beta-Secretase 1 - BACE-1 |
7609-5 |
Biovision |
|
EUR 262 |
Active Recombinant Human beta-Secretase 1 - BACE-1 |
7609-50 |
Biovision |
|
EUR 697 |
Recombinant Human MAPK1, Active Protein, Untagged, E.coli-1ug |
QP14023-1ug |
EnQuireBio |
1ug |
EUR 155 |
Recombinant Human MAPK1, Active Protein, Untagged, E.coli-5ug |
QP14023-5ug |
EnQuireBio |
5ug |
EUR 201 |
Recombinant Human MAPK1, Active Protein, Untagged, E.coli-100ug |
QP14023-EC-100ug |
EnQuireBio |
100ug |
EUR 2059 |
Recombinant Human Mitogen-Activated Protein Kinase 3, Active |
7-03937 |
CHI Scientific |
3µg |
Ask for price |
Treating PTPRF knockdown cells with GSK3 inhibitor rescued the expression of Wnt goal genes suggesting that PTPRF capabilities upstream of the β-catenin destruction complicated. PTPRF was discovered to work together with LRP6 and silencing PTPRF largely decreased the activation of LRP6. Interestingly, this PTPRF-mediated activation of Wnt signaling was blocked in cells handled with clathrin endocytosis inhibitor. Furthermore, knockdown of PTPRF inhibited xenograft tumor development in vivo and decreased the expression of Wnt goal genes. Taken collectively, our research establish a novel position of PTPRF as an oncogenic protein phosphatase in supporting the activation of Wnt signaling in CRC.