Articles by Judith Reynolds

Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma

Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a serious reason behind tumor related deaths globally. Annually, the prevalence of HCC is rising and the dearth of early prognostic indicators manifests a dismal prognosis for HCC sufferers. A deep…



Spindle and kinetochore-associated protein 2 facilitates the proliferation and invasion of hepatocellular carcinoma via the regulation of Wnt/β-catenin signaling

Spindle and kinetochore-associated protein 2 facilitates the proliferation and invasion of hepatocellular carcinoma via the regulation of Wnt/β-catenin signaling

Recent research have proven that spindle and kinetochore-associated protein 2 (SKA2) is dysregulated in a number of tumors and acts as a key regulator of tumor development. However, whether or not SKA2 performs a task…


Ark shell protein-derived bioactive peptides promote osteoblastic differentiation through upregulation of the canonical Wnt/β-catenin signaling in human bone marrow-derived mesenchymal stem cells

Ark shell protein-derived bioactive peptides promote osteoblastic differentiation through upregulation of the canonical Wnt/β-catenin signaling in human bone marrow-derived mesenchymal stem cells

In this research, the stimulating impact of ark shell protein-derived peptides AWLNH and PHDL on osteoblast differentiation in human bone marrow-derived mesenchymal stem cells (hBMMSCs) and its molecular mechanism was investigated. The hBMMSCs have been…


Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

Wnt-inducible Lrp6-APEX2 interacting proteins identify ESCRT machinery and Trk-fused gene as components of the Wnt signaling pathway

The canonical Wnt pathway serves as a hub connecting numerous mobile processes, together with β-catenin signaling, differentiation, development, protein stability, macropinocytosis, and nutrient acquisition in lysosomes. We have proposed that sequestration of β-catenin destruction complicated…


Zinc Finger Protein CTCF Regulates Extracellular Matrix (ECM)-Related Gene Expression Associated With the Wnt Signaling Pathway in Gastric Cancer

Zinc Finger Protein CTCF Regulates Extracellular Matrix (ECM)-Related Gene Expression Associated With the Wnt Signaling Pathway in Gastric Cancer

Gastric most cancers (GC), a number one reason for cancer-related dying, is a heterogeneous illness. We intention to explain clinically related molecular classifications of GC that incorporate heterogeneity and supply helpful medical data. We mixed…


Loss of mismatch repair signaling impairs the WNT-bone morphogenetic protein crosstalk and the colonic homeostasis.

Loss of mismatch repair signaling impairs the WNT-bone morphogenetic protein crosstalk and the colonic homeostasis.

The advantageous stability between proliferation, differentiation, and apoptosis in the colonic epithelium is tightly managed by the interaction between WNT, Notch, and bone morphogenetic protein (BMP) signaling. How these advanced networks coordinate the colonic homeostasis,…


Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Müller Cell-Localized G-Protein-Coupled Receptor 81 (Hydroxycarboxylic Acid Receptor 1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways.

Ischemic retinopathies are characterised by a progressive microvascular degeneration adopted by a postischemic aberrant neovascularization. To reinstate vascular provide and metabolic equilibrium to the ischemic tissue throughout ischemic retinopathies, a dysregulated manufacturing of progress components…


Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling

Liraglutide suppresses production of extracellular matrix proteins and ameliorates renal injury of diabetic nephropathy by enhancing Wnt/β-catenin signaling

The Wnt/β-catenin signaling pathway is concerned within the production of extracellular matrix (ECM) by mesangial cells (MCs). Recent research by us and others demonstrated that glucagon-like peptide-1 receptor agonists (GLP-1RAs) have protecting results in opposition…


Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression

Pancreatic cancer drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression

Today, pancreatic cancer (PC) is a serious well being downside within the United States. It stays a problem to develop efficacious clinically helpful PC therapies. New avenues, primarily based on translational approaches and progressive validated…