Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma

Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a serious reason behind tumor related deaths globally. Annually, the prevalence of HCC is rising and the dearth of early prognostic indicators manifests a dismal prognosis for HCC sufferers. A deep understanding of the molecular occasions that promote HCC development are required for the design of recent diagnostics and therapeutics. Dermatopontin (DPT) is an extracellular matrix protein that regulates the metastatic phenotypes of many cancers.
However, the results of DPT on HCC cell development stay undefined. In this examine, we display that the exogenous expression of DPT inhibits HCC cell development each in vitro and in vivo. Furthermore, we present that DPT regulates CXXC4, which in flip targets c-Myc, EZH2, SOX2 and β-catenin, by its capacity to influence Wnt signaling pathway. These knowledge counsel that DPT regulates CXXC4, c-Myc, EZH2, SOX2 and β-catenin, by Wnt signaling to repress HCC proliferation. This highlights DPT as promising goal for future HCC diagnostics and therapeutic targets.

Inhibition of protein tyrosine phosphatase receptor kind F suppresses Wnt signaling in colorectal most cancers

Wnt signaling dysregulation promotes tumorigenesis in colorectal most cancers (CRC). We investigated the function of PTPRF, a receptor-type tyrosine phosphatase, in regulating Wnt signaling in CRC. Knockdown of PTPRF decreased cell proliferation in patient-derived major colon most cancers cells and established CRC cell traces. In addition, the speed of proliferation in addition to colony formation capacity have been considerably decreased in tumor organoids grown in 3D, whereas the variety of differentiated tumor organoids have been markedly elevated. Consistently, knockdown of PTPRF resulted in a lower in the expression of genes related to most cancers stem cells downstream of Wnt/β-catenin signaling.
Treating PTPRF knockdown cells with GSK3 inhibitor rescued the expression of Wnt goal genes suggesting that PTPRF capabilities upstream of the β-catenin destruction complicated. PTPRF was discovered to work together with LRP6 and silencing PTPRF largely decreased the activation of LRP6. Interestingly, this PTPRF-mediated activation of Wnt signaling was blocked in cells handled with clathrin endocytosis inhibitor. Furthermore, knockdown of PTPRF inhibited xenograft tumor development in vivo and decreased the expression of Wnt goal genes. Taken collectively, our research establish a novel function of PTPRF as an oncogenic protein phosphatase in supporting the activation of Wnt signaling in CRC.

P38 mitogen-activated protein kinase promotes Wnt/β-catenin signaling by impeding Dickkofp-1 expression throughout Haemophilus parasuis an infection

Haemophilus parasuis induces extreme acute systemic an infection in pigs, characterised by fibrinous polyserositis, polyarthritis and meningitis. Our earlier examine demonstrated that H. parasuis induced the activation of p38 mitogen-activated protein kinase (MAPK) pathway, rising the expression of proinflammatory genes and mediating H. parasuis-induced irritation.
Moreover, Wnt/β-catenin signaling activation induced by H. parasuis disrupts the adherens junction between epithelial cells and initiates the epithelial-mesenchymal transition (EMT). In the current examine, p38 MAPK was discovered to be concerned in the buildup of nuclear location of β-catenin throughout H. parasuis an infection in PK-15 and NPTr cells, via modulating the expression of dickkofp-1 (DKK-1), a detrimental regulator of Wnt/β-catenin signaling.
We generated DKK-1 knockout cell traces by CRISPR/Cas9-mediated genome enhancing in PK-15 and NPTr cells, and located that knockout of DKK-1 led to the dysfunction of p38 MAPK in regulating Wnt/β-catenin signaling exercise in H. parasuis-infected cells. Furthermore, p38 MAPK exercise was unbiased of the activation of Wnt/β-catenin signaling throughout H. parasuis an infection. This is the primary examine to discover the crosstalk between p38 MAPK and Wnt/β-catenin signaling throughout H. parasuis an infection. It gives a extra complete view of intracellular signaling pathways throughout pathogenic bacteria-induced acute irritation.
Dermatopontin inhibits WNT signaling pathway via CXXC finger protein 4 in hepatocellular carcinoma

Pancreatic most cancers drug-sensitivity predicted by synergy of p53-Activator Wnt Inhibitor-2 (PAWI-2) and protein biomarker expression

Today, pancreatic most cancers (PC) is a serious well being downside in the United States. It stays a problem to develop efficacious clinically helpful PC therapies. New avenues, primarily based on translational approaches and progressive validated biomarkers may very well be a preclinical choice to guage PC drug candidates or drug combos earlier than scientific trials. Herein, we describe analysis of mixture therapies by incorporating a novel pathway modulator, p53-Activator Wnt Inhibitor-2 (PAWI-2) with different FDA-approved most cancers medicine which have been used in PC scientific trials.
PAWI-2 is a potent inhibitor of drug-resistant PC cells that has been proven to selectively ameliorate human pancreatic most cancers stem cells (i.e., hPCSCs, FGβ3 cells). In the current examine, we confirmed PAWI-2 produced therapeutic synergism with sure kinds of anti-cancer medicine. These medicine themselves oftentimes don’t ameliorate PC cells (particularly PCSCs) as a result of excessive ranges of drug-resistance. PAWI-2 has the flexibility to rescue the efficiency of medication (i.e., erlotinib, trametinib) and inhibit PC cell development. Key molecular regulators of PAWI-2 may very well be used to foretell synergistic/antagonistic results between PAWI-2 and different anti-cancer medicine.
Anti-cancer outcomes confirmed efficiency may very well be fairly precisely correlated to phosphorylation of optineurin (OPTN) in PC cells. Synergism/antagonism was additionally related to inhibition of PCSC marker SOX2 that was noticed in FGβ3 cells. Synergism broadens the potential use of PAWI-2 as an adjunct chemotherapy in sufferers with PC which have developed resistance to first-line focused therapies or chemotherapies.

Phosphatidylinositol 4-phosphate adaptor protein 2 accelerates the proliferation and invasion of hepatocellular carcinoma cells by enhancing Wnt/β-catenin signaling

Phosphatidylinositol 4-phosphate adaptor protein 2 (FAPP2) has been just lately recognized as a tumor-associated regulator that’s intently associated to tumorigenesis. Yet, the exact function of FAPP2 in hepatocellular carcinoma (HCC) remains to be largely unknown. This examine was designed to find out the perform and molecular mechanisms of FAPP2 in HCC.
Elevated expression of FAPP2 generally occurred in the tumor tissue of HCC in contrast with regular controls. High expression of FAPP2 was additionally detected in HCC cell traces and its knockdown markedly decreased the proliferation, colony formation and invasion of HCC cells. Upregulation of FAPP2 by utilizing a FAPP2 expression vector markedly promoted the proliferation, colony formation and invasion of HCC cells. FAPP2 was discovered to advertise the activation of Wnt/β-catenin signaling.

Goat Milk Proteins Sample Diluent

F243A-100 100 ml
EUR 257
  • Product category: Buffer solution
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A-500 500 ml
EUR 411
  • Product category: Buffer solution
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Antigen Concentrate

F243H 100 ul
EUR 411
  • Product category: Quality control/standard for molecular biology applications
Description: Goat Milk Proteins Antigen Concentrate by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Control Antigen

F247 50 ul
EUR 257
  • Product category: Quality control/standard for molecular biology applications
Description: Goat Milk Proteins Control Antigen by Cygnus Technologies is available in Europe via Gentaur.

Total Goat Milk Proteins ELISA kit

F240 1 kit (96 wells plate)
EUR 1080
  • Product category: Enzyme linked immunosorbent assay (ELISA) kit.
Description: Total Goat Milk Proteins ELISA kit by Cygnus Technologies is available in Europe via Gentaur.

Total Goat Milk Proteins WB kit

F245 1 kit (application dependant amount of reactions)
EUR 836
  • Product category: Premade blotting kit
Description: Total Goat Milk Proteins WB kit by Cygnus Technologies is available in Europe via Gentaur.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-milk fat globulin antibody

STJ16100177 100 µg
EUR 406

Human milk specific allergen antibody(IgE) ELISA Kit

CSB-E15859h-24T 1 plate of 24 wells
EUR 165
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human milk specific allergen antibody (IgE) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human milk specific allergen antibody(IgE) ELISA Kit

1-CSB-E15859h
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
  • Sample volume: 50-100ul
  • Detection wavelength: 450nm
  • Assay performance time: 1 to 4 hours.
Description: Quantitativesandwich ELISA kit for measuring Human milk specific allergen antibody(IgE) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Anti-Goat Milk Proteins:HRP Conjugate

F241 12 ml
EUR 488
  • Product category: Antibodies
Description: Anti-Goat Milk Proteins:HRP Conjugate by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04 1 ml
EUR 334
  • Product category: Antibodies
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04-AF 1 mg
EUR 1913
  • Product category: Antibodies
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04-PA 1 ml
EUR 488
  • Product category: Antibodies
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04AF-HRP 100 ul
EUR 989
  • Product category: Antibodies
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Skim Milk

abx082021-100g 100 g
EUR 217
  • Shipped within 5-10 working days.

anti-Human Milk Fat Globule 1

YF-PA13135 50 ug
EUR 363
Description: Mouse polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA13136 100 ul
EUR 403
Description: Rabbit polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA13137 100 ug
EUR 403
Description: Rabbit polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA24148 50 ul
EUR 334
Description: Mouse polyclonal to Human Milk Fat Globule 1

Anti-Human Milk Fat Globule 1/MFGE8 Antibody

PA1945 100ug/vial
EUR 334

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Lys proteins Antibody

DF2705 200ul
EUR 304
Description: Lys proteins antibody detects endogenous levels of total Lys proteins.

Lys proteins Antibody

abx219526-100ug 100 ug
EUR 439
  • Shipped within 5-10 working days.

Lys proteins Antibody

ABD2705 100 ug
EUR 438

anti- OCT2-Specific antibody

FNab05962 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: POU class 2 homeobox 2
  • Uniprot ID: P09086
  • Gene ID: 5452
  • Research Area: Cancer, Immunology, Metabolism, Developmental biology
Description: Antibody raised against OCT2-Specific

anti- Oct6-Specific antibody

FNab05965 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: POU class 3 homeobox 1
  • Uniprot ID: Q86VW1
  • Research Area: Neuroscience, Metabolism, Developmental biology
Description: Antibody raised against Oct6-Specific

anti- ORM2-Specific antibody

FNab06014 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:5000
  • IF: 1:50-1:500
  • Immunogen: orosomucoid 2
  • Uniprot ID: P19652
  • Research Area: Cardiovascular
Description: Antibody raised against ORM2-Specific

anti- PACS2-Specific antibody

FNab06099 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • IF: 1:10-1:100
  • Immunogen: phosphofurin acidic cluster sorting protein 2
  • Uniprot ID: Q86VP3
  • Research Area: Cell Division and Proliferation
Description: Antibody raised against PACS2-Specific

anti- Palladin-Specific antibody

FNab06127 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:200-1:1000
  • Immunogen: palladin, cytoskeletal associated protein
  • Uniprot ID: Q8WX93
  • Research Area: Neuroscience, Immunology
Description: Antibody raised against Palladin-Specific

anti- PAX1-Specific antibody

FNab06167 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: paired box 1
  • Uniprot ID: P15863
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against PAX1-Specific

anti- PAX8-Specific antibody

FNab06177 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: paired box 8
  • Uniprot ID: Q06710
  • Research Area: Cancer, Immunology, Metabolism, Developmental biology
Description: Antibody raised against PAX8-Specific

anti- persephin-Specific antibody

FNab06323 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: persephin
  • Uniprot ID: O60542
  • Research Area: Neuroscience, Developmental biology
Description: Antibody raised against persephin-Specific

anti- PFKFB3-Specific antibody

FNab06339 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:50-1:200
  • IF: 1:20-1:200
  • Immunogen: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  • Uniprot ID: Q16875
  • Gene ID: 5209
  • Research Area: Metabolism
Description: Antibody raised against PFKFB3-Specific

anti- PKM1-specific antibody

FNab06494 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:500-1:2000
  • IHC: 1:100-1:400
  • IF: 1:20-1:200
  • Immunogen: PKM2 pyruvate kinase, muscle
  • Uniprot ID: P14618
  • Research Area: Stem Cells, Cancer, Cardiovascular, Metabolism
Description: Antibody raised against PKM1-specific

anti- PKM2-specific antibody

FNab06495 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000-1:4000
  • IP: 1:200-1:1000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • Immunogen: PKM2 pyruvate kinase, muscle
  • Uniprot ID: P14618
  • Research Area: Stem Cells, Cancer, Cardiovascular, Metabolism
Description: Antibody raised against PKM2-specific

anti- PKM2-specific antibody

FNab06496 100µg
EUR 548.75
  • Recommended dilution: WB: 1:2000-1:16000
  • IP: 1:200-1:1000
  • IHC: 1:100-1:1000
  • IF: 1:20-1:200
  • Immunogen: PKM2 pyruvate kinase, muscle
  • Uniprot ID: P14618
  • Research Area: Stem Cells, Cancer, Cardiovascular, Metabolism
Description: Antibody raised against PKM2-specific

anti- PLOD2-Specific antibody

FNab06552 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:200-1:1000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • Immunogen: procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
  • Uniprot ID: O00469
  • Research Area: Metabolism
Description: Antibody raised against PLOD2-Specific

anti- POLR2B-Specific antibody

FNab06620 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:5000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: polymerase(RNA) II(DNA directed) polypeptide B, 140kDa
  • Uniprot ID: P30876
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against POLR2B-Specific

anti- POTEA-Specific antibody

FNab06647 100µg
EUR 585
  • Recommended dilution: IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: POTE ankyrin domain family, member A
  • Uniprot ID: Q6S8J7
  • Research Area: Cell Division and Proliferation
Description: Antibody raised against POTEA-Specific

anti- POTED-Specific antibody

FNab06648 100µg
EUR 585
  • Recommended dilution: WB 1:500-1:1000
  • IHC 1:50-1:100
  • Immunogen: POTE ankyrin domain family, member D
  • Uniprot ID: Q86YR6
  • Gene ID: 317754
  • Research Area: Cell Division and Proliferation
Description: Antibody raised against POTED-Specific

anti- POU3F3-Specific antibody

FNab06651 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • Immunogen: POU class 3 homeobox 3
  • Uniprot ID: P20264
  • Research Area: Neuroscience, Metabolism, Developmental biology
Description: Antibody raised against POU3F3-Specific

anti- PPIF-Specific antibody

FNab06676 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • IP: 1:500-1:2000
  • Immunogen: peptidylprolyl isomerase F
  • Uniprot ID: P30405
  • Research Area: Metabolism
Description: Antibody raised against PPIF-Specific

anti- PPP1CB-Specific antibody

FNab06695 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • IP: 1:500-1:2000
  • Immunogen: protein phosphatase 1, catalytic subunit, beta isoform
  • Uniprot ID: P62140
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against PPP1CB-Specific

anti- PPP1R11-Specific antibody

FNab06699 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: protein phosphatase 1, regulatory(inhibitor) subunit 11
  • Uniprot ID: O60927
  • Research Area: Metabolism
Description: Antibody raised against PPP1R11-Specific

anti- PSEN2-Specific antibody

FNab06853 100µg
EUR 548.75
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: presenilin 2(Alzheimer disease 4)
  • Uniprot ID: P49810
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Immunology, Neuroscience
Description: Antibody raised against PSEN2-Specific

anti- PTH-Specific antibody

FNab06923 100µg
EUR 585
  • Recommended dilution: WB: 1:1000-1:4000
  • Immunogen: parathyroid hormone
  • Uniprot ID: P01270
  • Gene ID: 5741
  • Research Area: Cancer, Immunology, Signal Transduction, Developmental biology
Description: Antibody raised against PTH-Specific

anti- PYGM-Specific antibody

FNab06977 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: phosphorylase, glycogen, muscle
  • Uniprot ID: P11217
  • Gene ID: 5837
  • Research Area: Metabolism
Description: Antibody raised against PYGM-Specific

anti- RAB11B-Specific antibody

FNab06989 100µg
EUR 505.25
  • Recommended dilution: WB: 1:300-1:600
  • IHC: 1:20-1:200
  • Immunogen: RAB11B, member RAS oncogene family
  • Uniprot ID: Q15907
  • Gene ID: 9230
  • Research Area: Signal Transduction
Description: Antibody raised against RAB11B-Specific

anti- RAB11-Specific antibody

FNab06994 100µg
EUR 505.25
  • Immunogen: RAB11A, member RAS oncogene family
  • Uniprot ID: P62491
  • Research Area: Signal Transduction
Description: Antibody raised against RAB11-Specific

anti- RAB22A-specific antibody

FNab07005 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: RAB22A, member RAS oncogene family
  • Uniprot ID: Q9UL26
  • Research Area: Signal Transduction
Description: Antibody raised against RAB22A-specific

anti- RAB27A-specific antibody

FNab07011 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: RAB27A, member RAS oncogene family
  • Uniprot ID: P51159
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against RAB27A-specific

anti- RAB31-specific antibody

FNab07015 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: RAB31, member RAS oncogene family
  • Uniprot ID: Q13636
  • Research Area: Signal Transduction
Description: Antibody raised against RAB31-specific

anti- RAB3A-specific antibody

FNab07025 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:50-1:500
  • IF: 1:10-1:100
  • Immunogen: RAB3A, member RAS oncogene family
  • Uniprot ID: P20336
  • Research Area: Signal Transduction
Description: Antibody raised against RAB3A-specific

anti- RAB3C-specific antibody

FNab07028 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IF: 1:10-1:100
  • Immunogen: RAB3C, member RAS oncogene family
  • Uniprot ID: Q96E17
  • Research Area: Signal Transduction
Description: Antibody raised against RAB3C-specific

anti- RAB5A-Specific antibody

FNab07039 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:50-1:500
  • Immunogen: RAB5A, member RAS oncogene family
  • Uniprot ID: P20339
  • Gene ID: 5868
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against RAB5A-Specific

anti- RAB9A-Specific antibody

FNab07049 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: RAB9A, member RAS oncogene family
  • Research Area: Signal Transduction
Description: Antibody raised against RAB9A-Specific

anti- REDD1 specific antibody

FNab07228 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IP: 1:200-1:2000
  • IHC: 1:50-1:200
  • Immunogen: DNA-damage-inducible transcript 4
  • Uniprot ID: Q9NX09
  • Gene ID: 54541
  • Research Area: Epigenetics, Immunology, Cardiovascular
Description: Antibody raised against REDD1 specific

anti- RIM2-Specific antibody

FNab07301 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: regulating synaptic membrane exocytosis 2
  • Uniprot ID: Q9UQ26
  • Research Area: Neuroscience
Description: Antibody raised against RIM2-Specific

anti- RIMS4-Specific antibody

FNab07305 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: regulating synaptic membrane exocytosis 4
  • Uniprot ID: Q9H426
  • Research Area: Neuroscience
Description: Antibody raised against RIMS4-Specific

anti- RIPK1-Specific antibody

FNab07313 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IP: 1:200-1:1000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • Immunogen: receptor(TNFRSF)-interacting serine-threonine kinase 1
  • Uniprot ID: Q13546
  • Research Area: Immunology, Signal Transduction, Metabolism
Description: Antibody raised against RIPK1-Specific

anti- ROBO1-Specific antibody

FNab07372 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: roundabout, axon guidance receptor, homolog 1(Drosophila)
  • Uniprot ID: Q9Y6N7
  • Research Area: Neuroscience, Immunology, Cardiovascular, Developmental biology
Description: Antibody raised against ROBO1-Specific

anti- ROBO3-Specific antibody

FNab07374 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: roundabout, axon guidance receptor, homolog 3(Drosophila)
  • Uniprot ID: Q96MS0
  • Research Area: Neuroscience, Stem Cells, Cardiovascular, Developmental biology
Description: Antibody raised against ROBO3-Specific

anti- ROBO4-Specific antibody

FNab07375 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: roundabout homolog 4, magic roundabout(Drosophila)
  • Uniprot ID: Q8WZ75
  • Research Area: Immunology, Cardiovascular, Developmental biology
Description: Antibody raised against ROBO4-Specific

anti- ROCK1-Specific antibody

FNab07377 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:20-1:200
  • Immunogen: Rho-associated, coiled-coil containing protein kinase 1
  • Uniprot ID: Q13464
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biology, Cell Division
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Description: Antibody raised against ROCK1-Specific

anti- ROCK2-Specific antibody

FNab07379 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: Rho-associated, coiled-coil containing protein kinase 2
  • Uniprot ID: O75116
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Cancer, Developmental biolog
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Description: Antibody raised against ROCK2-Specific

anti- RRM1-Specific antibody

FNab07495 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IF: 1:10-1:100
  • Immunogen: ribonucleotide reductase M1
  • Uniprot ID: P23921
  • Gene ID: 6240
  • Research Area: Cancer, Immunology, Metabolism
Description: Antibody raised against RRM1-Specific

anti- RtcB-Specific antibody

FNab07515 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000-1:4000
  • IP: 1:500-1:1000
  • IF: 1:10-1:100
  • Immunogen: chromosome 22 open reading frame 28
  • Uniprot ID: Q9Y3I0
Description: Antibody raised against RtcB-Specific

anti- SEC61B-Specific antibody

FNab07691 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000-1:4000
  • IF: 1:20-1:200
  • IHC: 1:20-1:200
  • Immunogen: Sec61 beta subunit
  • Uniprot ID: P60468
  • Research Area: Metabolism
Description: Antibody raised against SEC61B-Specific

anti- SENP5-Specific antibody

FNab07714 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: SUMO1/sentrin specific peptidase 5
  • Uniprot ID: Q96HI0
  • Research Area: Metabolism
Description: Antibody raised against SENP5-Specific

anti- SERINC2-Specific antibody

FNab07736 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: serine incorporator 2
  • Uniprot ID: Q96SA4
  • Research Area: Metabolism
Description: Antibody raised against SERINC2-Specific

anti- SIRT2-Specific antibody

FNab07880 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: sirtuin(silent mating type information regulation 2 homolog) 2(S. cerevisiae)
  • Uniprot ID: Q8IXJ6
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against SIRT2-Specific

anti- SLC12A5-Specific antibody

FNab07908 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • Immunogen: solute carrier family 12(potassium-chloride transporter), member 5
  • Uniprot ID: Q9H2X9
  • Research Area: Signal Transduction
Description: Antibody raised against SLC12A5-Specific

anti- SLC25A6-Specific antibody

FNab07947 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: solute carrier family 25(mitochondrial carrier
  • adenine nucleotide translocator), member 6
  • Uniprot ID: P12236
  • Research Area: Metabolism
Description: Antibody raised against SLC25A6-Specific

anti- SMYD1-Specific antibody

FNab08047 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: SET and MYND domain containing 1
  • Uniprot ID: Q8NB12
  • Research Area: Metabolism
Description: Antibody raised against SMYD1-Specific

anti- Somatostatin-Specific antibody

FNab08109 100µg
EUR 548.75
  • Recommended dilution: IHC: 1:4000-1:16000
  • Immunogen: somatostatin
  • Uniprot ID: P61278
  • Research Area: Signal Transduction, Metabolism, Immunology, Cancer, Neuroscience, Stem Cells
Description: Antibody raised against Somatostatin-Specific

anti- SPAG4-Specific antibody

FNab08142 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: sperm associated antigen 4
  • Uniprot ID: Q9NPE6
  • Research Area: Developmental biology
Description: Antibody raised against SPAG4-Specific

anti- SPIN1-Specific antibody

FNab08178 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: spindlin 1
  • Uniprot ID: Q9Y657
  • Research Area: Developmental biology
Description: Antibody raised against SPIN1-Specific

anti- SPTBN1-Specific antibody

FNab08204 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IP:1:200-1:2000
  • IHC: 1:20-1:200
  • Immunogen: spectrin, beta, non-erythrocytic 1
  • Uniprot ID: Q01082
  • Research Area: Signal Transduction
Description: Antibody raised against SPTBN1-Specific

anti- SRGAP3-Specific antibody

FNab08227 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: SLIT-ROBO Rho GTPase activating protein 3
  • Uniprot ID: O43295
  • Research Area: Signal Transduction
Description: Antibody raised against SRGAP3-Specific

anti- ST8SIA2-Specific antibody

FNab08276 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 2
  • Uniprot ID: Q92186
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against ST8SIA2-Specific

anti- STEAP2-Specific antibody

FNab08317 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: six transmembrane epithelial antigen of the prostate 2
  • Uniprot ID: Q8NFT2
  • Research Area: Metabolism
Description: Antibody raised against STEAP2-Specific

anti- SYN1-Specific antibody

FNab08416 100µg
EUR 548.75
  • Recommended dilution: WB: 1:2000-1:20000
  • IP: 1:1000-1:10000
  • Immunogen: synapsin I
  • Uniprot ID: P17600
  • Research Area: Neuroscience, Metabolism
Description: Antibody raised against SYN1-Specific

anti- TAF1-Specific antibody

FNab08484 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:20-1:200
  • Immunogen: TAF1 RNA polymerase II, TATA box binding protein(TBP)-associated factor, 250kDa
  • Uniprot ID: P21675
  • Research Area: Metabolism
Description: Antibody raised against TAF1-Specific

anti- TDRKH specific antibody

FNab08580 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:3000
  • IP: 1:200-1:1400
  • IHC: 1:50-1:500
  • IF: 1:50-1:500
  • Immunogen: tudor and KH domain containing
  • Uniprot ID: Q9Y2W6
  • Research Area: Metabolism
Description: Antibody raised against TDRKH specific

anti- TGFBR3-Specific antibody

FNab08645 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: transforming growth factor, beta receptor III
  • Uniprot ID: Q03167
  • Research Area: Immunology, Cardiovascular, Developmental biology, Signal Transduction
Description: Antibody raised against TGFBR3-Specific

anti- TINAG-Specific antibody

FNab08712 100µg
EUR 585
  • Recommended dilution: WB: 1:500 - 1:3000
  • IHC: 1:20 - 1:200
  • Immunogen: tubulointerstitial nephritis antigen
  • Uniprot ID: Q9UJW2
  • Research Area: Cardiovascular, Metabolism
Description: Antibody raised against TINAG-Specific

anti- TMF1-Specific antibody

FNab08796 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: TATA element modulatory factor 1
  • Uniprot ID: P82094
  • Research Area: Metabolism
Description: Antibody raised against TMF1-Specific

anti- TOP2A-Specific antibody

FNab08868 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:3000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: topoisomerase(DNA) II alpha 170kDa
  • Uniprot ID: P11388
  • Research Area: Epigenetics, Cell Division and Proliferation, Metabolism
Description: Antibody raised against TOP2A-Specific

anti- GAB3-Specific antibody

FNab03273 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: GRB2-associated binding protein 3
  • Uniprot ID: Q8WWW8
  • Research Area: Signal Transduction, Developmental biology
Description: Antibody raised against GAB3-Specific

anti- GABARAPL1-Specific antibody

FNab03276 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: GABA(A) receptor-associated protein like 1
  • Uniprot ID: Q9H0R8
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against GABARAPL1-Specific

anti- GABARAPL2-Specific antibody

FNab03278 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: GABA(A) receptor-associated protein-like 2
  • Uniprot ID: P60520
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against GABARAPL2-Specific

anti- GAC-specific antibody

FNab03290 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:100-1:400
  • Immunogen: glutaminase
  • Uniprot ID: O94925
  • Research Area: Neuroscience, Metabolism
Description: Antibody raised against GAC-specific

anti- GATA4-Specific antibody

FNab03363 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: GATA binding protein 4
  • Uniprot ID: P43694
  • Gene ID: 2626
  • Research Area: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Stem Cell
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Description: Antibody raised against GATA4-Specific
Importantly, inhibition of Wnt/β-catenin signaling abrogated the FAPP2 overexpression-conferred oncogenic impact in HCC cells. In addition, xenograft tumor experiments revealed that knockdown of FAPP2 considerably decreased the tumorigenicity of HCC cells in vivo. Taken collectively, the info of our examine reported a tumor-promotion perform of FAPP2 in HCC and display that knockdown of FAPP2 was able to suppressing HCC cell proliferation and invasion by downregulation of Wnt/β-catenin signaling. This examine indicated that FAPP2 may be a horny candidate anticancer goal for HCC.