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Histone methylation
Acetylation
DNA proteine interaction
DNA modification
NIPP1a
NIPP1b
PP1
HOXa2 33
HOXa2 17

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NIPP-1, His•Tag, Recombinant,Bovine Thymus,  E. coli

Nuclear Inhibitor of Protein Phosphatase-1

Bovine NIPP-1 fused to a His•Tag. Recombinant protein,  sequenced and expressed in E. coli. Specific and very potent  inhibitor of protein phosphatase 1 (PP1; Ki = 1-10 pM). It can be used to distinguish PP1 from other major serine/threonine protein phosphatases including PP2A, PP2B, and PP2C. Also an ideal substrate for protein kinase A and casein kinase II. Thought to be involved in the targeting of PP1 to RNA-associated substrates and may also be involved in the dephosphorylation of transcription factors like CREB and the tumor suppressor Rb.

 

ordering number size quantity price
04-NIPP1-5ug 5μg   300,00

 

Product information:

form liquid
formultion In 500 mM NaCl,pH 7.5,500 µM benzamidine, 20 mM Tris, 500 µM PMSF, 5 µM leupeptin
primary target PP1
Primary Target Ki 1-10 pM
Avoid freeze/thaw yes
Purity ≥92% by SDS-PAGE

 

Store and ship information:

storage -20°C
ship dry ice only
standard handling

 

Central Fragment of NIPP-1 (residues 143-224), His•Tag, Recombinant,Bovine Thymus,  E. coli

 

EFFICIENCY - Ic50 = 0,2 μM !!!

MORE STABLE IN HIGH TEMPERATURES !!!

 

Inhibitor of Protein Phosphatase-1

Fragment of NIPP-1 (residues 143-224) fused to a His•Tag. Recombinant protein,  sequenced and expressed in E. coli. Specific and very potent  inhibitor of protein phosphatase 1. It can be used to distinguish PP1 from other major serine/threonine protein phosphatases including PP2A, PP2B, and PP2C. Also an ideal substrate for protein kinase A and casein kinase II. Thought to be involved in the targeting of PP1 to RNA-associated substrates and may also be involved in the dephosphorylation of transcription factors like CREB and the tumor suppressor Rb.

 

ordering number size quantity price
04-FRNIPP1-5ug 5μg   500,00

 

Product information:

form liquid
formultion In 500 mM NaCl,pH 7.5,500 µM benzamidine, 20 mM Tris, 500 µM PMSF, 5 µM leupeptin
primary target PP1
Avoid freeze/thaw yes
Purity ≥92% by SDS-PAGE

 

Store and ship information:

storage -20°C
ship dry ice only
standard handling

 

 

 

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